Browse the evidence

The policy change of covering anti-obesity medications is likely to increase Medicare costs by low to middle tens of billions of dollars over ten years.

Practitioners should prepare for the potential long-term financial impact of Medicare's coverage of anti-obesity medications.

Nose-to-brain (N2B) pathways can address limitations of the subcutaneous route for GLP-1 RAs.

Practitioners should explore N2B pathways as a viable alternative for delivering GLP-1 RAs.

Obesity prevalence is projected to grow by 40% in the next decade.

Health professionals should prepare for increased obesity-related health issues.

There were no significant changes in peak VO2 or other cardiovascular measures with HU6 treatment.

HU6 may not improve cardiovascular function despite weight loss.

25,215 adverse event reports related to tirzepatide were identified, predominantly in the 65 to 85 age group.

Healthcare providers should be aware of the high volume of AE reports in older adults using tirzepatide.

Novel adverse event signals include thyroid mass, medullary thyroid carcinoma, and conditions affecting the reproductive system and breast.

Clinicians should be vigilant for these specific adverse events in patients treated with tirzepatide.

A biomimetic and comparative approach can provide insights into human ageing processes.

Practitioners should consider integrating insights from diverse species to enhance understanding of ageing.

Multiple hallmarks of ageing have been identified that are fundamental across taxa.

Understanding these hallmarks can guide research and interventions in age-related diseases.

There is a need for renewed focus in the pathophysiology of ageing and age-related disease.

Researchers should explore new avenues in the study of ageing and related diseases.

Nonalcoholic fatty liver disease (NAFLD) affects approximately 25% of the global population.

Healthcare providers should be aware of the high prevalence of NAFLD in their patient populations.

The direct to consumer genetic testing market is estimated to total about $100 million in 2017.

Practitioners should be aware of the significant financial scale of the DTC genetic testing market.

The need for more effective treatments for obesity is obvious due to the far-reaching effects of the condition.

Healthcare providers should prioritize finding effective obesity treatments.

2/3 of American adults and 1/6 of American children and adolescents are considered either overweight or obese.

Health professionals should be aware of the high prevalence of overweight and obesity in the population.

Innovative engineering technologies are needed to address problems in energy balance, intake, and expenditure associated with obesity.

There is a need for collaboration between engineers and health scientists to develop effective obesity interventions.

Ingestion of deuterated water results in 2 H enrichment of the body water pool, which is incorporated into tissue proteins.

This highlights a novel approach to studying protein synthesis in muscle tissue.

There is limited clinical trial data on the safety and efficacy of anti-obesity medications for patients with heart failure.

Practitioners should be aware of the limited evidence when considering anti-obesity medications for heart failure patients.

The prevalence of obesity has increased markedly in recent decades, constituting major medical and socioeconomic problems worldwide.

Awareness of the obesity epidemic is crucial for public health initiatives.

The most common adverse events associated with semaglutide are gastrointestinal in nature.

Healthcare providers should inform patients about potential gastrointestinal side effects when prescribing semaglutide.

Ex-DARPin fusion proteins injected at 25 nmol/kg every three days significantly lowered blood glucose, inhibited food consumption, and reduced body weight for 30 days in STZ-induced diabetic mice.

Ex-DARPin fusion proteins may be a promising treatment for managing blood glucose and weight in diabetic patients.

Ex-DARPin fusion proteins have a comparable half-life of 29-32 hours, which is much longer than that of native Ex (0.5 hours in rats).

Longer half-life of Ex-DARPin fusion proteins may reduce the frequency of administration needed for effective treatment.

Ex-DARPin fusion proteins significantly improved the survival of pancreatic islets in diabetic mice.

Improving pancreatic islet survival could enhance insulin production and overall diabetes management.

There are currently no clear guidelines for the prehabilitation of obese patients with dysglycemia undergoing bariatric surgery.

Healthcare providers should recognize the need for developing guidelines for prehabilitation in this patient population.

Current community-based lifestyle modification programs are unlikely to be effective in preventing diabetes.

Reassess the design and implementation of lifestyle modification programs for diabetes prevention.

Patients with coronary artery disease (CAD) have a lower capillary-to-fiber ratio (C/Fi) and capillary-to-fiber perimeter exchange (CFPE) index in Type II fibers compared to healthy controls.

Understanding these differences can inform targeted rehabilitation strategies for CAD patients.