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Tirzepatide is the first dual receptor agonist incorporated into therapeutic recommendations for type 2 diabetes.

Tirzepatide should be considered as a treatment option for type 2 diabetes.

There is a greater emphasis on adjunct pharmacotherapy in the updated guideline, particularly with GLP-1-based agents for weight reduction and improvement of comorbidities.

Healthcare providers should integrate GLP-1-based pharmacotherapy into obesity management strategies.

Insects can support skeletal muscle anabolism to the same extent as conventional animal protein.

Practitioners can consider insect protein as a sustainable alternative for muscle support.

Endoluminal interventions should be combined with a moderately intensive diet and lifestyle program lasting at least 12 months for optimal results.

Practitioners should integrate dietary and lifestyle counseling with endoluminal therapies for better outcomes.

Consuming protein three times a day results in an increase in lean mass of 1.15 kg after 8 weeks of resistance training.

Practitioners can recommend three protein meals per day to support muscle gain.

Consuming protein five times a day results in an increase in lean mass of 0.63 kg after 8 weeks of resistance training.

Practitioners can recommend five protein meals per day to support muscle gain.

Dietary supplementation may help optimise muscle health, particularly when combined with exercise or where a deficit may exist.

Practitioners may consider recommending specific dietary supplements to enhance muscle health in non-athlete adults.

Binge eating episodes and prevalence reduced following liraglutide and semaglutide.

Practitioners may find liraglutide and semaglutide effective in reducing binge eating behaviors in patients.

PAP+tirzepatide was associated with lower incident PH at 1 year (RR:0.27) and 3 years (RR:0.22), and lower mortality at 1 year (RR:0.14) and 3 years (RR:0.12).

Using tirzepatide in conjunction with PAP may provide superior benefits in reducing PH and mortality for obese patients with OSA.

Compared to PAP+semaglutide, PAP+tirzepatide showed lower incident PH at 1 year (RR:0.51) and 3 years (RR:0.42) and lower all-cause mortality at 1 year (RR:0.41) and 3 years (RR:0.33).

Tirzepatide may offer enhanced benefits over semaglutide for reducing PH and mortality in obese patients with OSA on PAP.

Targeted resistance training combined with increased protein intake led to measurable improvements in strength and body composition.

Practitioners can implement low-effort resistance training and protein intake strategies to improve strength in patients with chronic lung disease.

Daily protein intake in patients' usual diets was below the recommended levels.

It is important to assess and address protein intake in patients with chronic lung disease.

Protein supplementation combined with resistance training significantly enhanced muscle strength (SMD = 0.45, 95% CI: 0.20, 0.69) and muscle mass (MD = 0.37, 95% CI: 0.04, 0.70).

Practitioners should consider recommending protein supplementation alongside resistance training for older adults to enhance muscle strength and mass.

The weekend warrior (WW) physical activity pattern is associated with significantly lower odds of sarcopenia compared to inactive individuals (OR 0.16; 95% CI, 0.07-0.35).

Encouraging high-intensity activity on weekends may help reduce sarcopenia risk in older adults.

Regularly active (RA) individuals also show reduced odds of sarcopenia compared to inactive individuals (OR 0.64; 95% CI, 0.52-0.79).

Encouraging regular physical activity can help reduce sarcopenia risk in older adults.

A plant-based eating pattern is non-inferior to an omnivore diet for athletic performance and muscle protein synthesis when macronutrient content is similar.

Athletes can achieve similar performance and muscle synthesis on a plant-based diet as on an omnivore diet if protein intake is adequate.

When sufficient total protein is consumed, plant-based sources are non-inferior to animal-based sources.

Athletes can rely on plant-based protein sources without compromising performance if protein intake is adequate.

A 40% energy surplus over 6 weeks significantly increased body protein mass by 3.7% (0.44 kg; 95% CI, 0.21-0.67 kg; P = 0.003).

Increasing energy intake significantly promotes body protein mass gain in healthy young men.

Resistance training alongside proper protein intake is important to mitigate the effects of aging on skeletal muscle tissue.

Health professionals should incorporate both resistance training and protein intake in programs for older adults.

Protein supplementation may provide benefits for individuals with previous training experience, those not meeting daily protein requirements, or displaying frailty symptoms.

Protein supplementation may be beneficial for certain subgroups of older adults.

Regular physical activity can optimize glucose regulation in individuals with diabetes mellitus.

Practitioners should encourage regular physical activity for diabetes management.

Aerobic exercise programs are effective for improving aerobic capacity and have positive metabolic effects.

Encouraging aerobic exercise can significantly benefit patients' metabolic health.

The SALUD program aims to improve food literacy in people with type 2 diabetes mellitus (T2DM).

Practitioners can utilize the SALUD program to enhance food literacy among T2DM patients.

The SALUD program includes 12 weekly web-based group sessions supervised by a certified lifestyle coach.

Health professionals can implement structured group sessions to support T2DM patients.