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Increases in MVPA accumulated in bouts of both <10 min and ≥10 min are associated with a lower risk of progression to CKD.

Incorporating both short and longer physical activity bouts can be beneficial for reducing CKD risk.

Participants in the weight loss program experienced a significant reduction in weight of -4.8±2.3 kg.

Weight loss programs can be effective for first responders with obesity.

Participants showed a significant reduction in percent body fat of -3.9±1.7%.

Effective weight loss programs can also lead to reductions in body fat.

The weight loss program is feasible for supporting career firefighters in their weight loss efforts.

Programs utilizing technology and coaching can effectively aid weight loss in first responders.

Low-carbohydrate diets are effective in reversing metabolic syndrome, with 1580 respondents reporting decreased waist circumference and weight, increased energy levels, and decreased hunger.

Practitioners may consider recommending low-carbohydrate diets for patients with metabolic syndrome.

The majority of respondents experienced improvements in laboratory values, including HbA1c, blood glucose measurements, and lipid panel results.

Practitioners can expect metabolic improvements in patients following low-carbohydrate diets.

Participants with higher adherence scores for an overall low-carbohydrate diet (LCD) exhibited lower odds of hepatic steatosis (OR = 0.76, 95% CI: 0.61-0.96, p trend = 0.049).

Encouraging adherence to low-carbohydrate diets may reduce the risk of hepatic steatosis.

Replacing 5% of the energy from carbohydrates with total fat and protein is associated with lower steatosis prevalence (OR = 0.91, 95% CI: 0.83-0.99).

Modifying carbohydrate intake by increasing fat and protein may help lower the risk of hepatic steatosis.

Traditional-set structure (TRAD) resulted in significantly greater velocity loss magnitude (g = 1.50) compared to cluster-set structure (CLUS).

Using traditional-set structures may enhance performance metrics like velocity loss during resistance training.

Traditional-set structure (TRAD) showed greater muscle thickness of the proximal pectoralis major (g = -0.34) compared to cluster-set structure (CLUS).

Traditional-set structures may lead to better hypertrophy outcomes in the proximal pectoralis major.

Substitution of low- and no-calorie sweetened beverages (LNCSBs) for sugar-sweetened beverages (SSBs) was associated with a reduction in body weight by 1.06 kg (95% CI, -1.71 to -0.41 kg).

Practitioners may consider recommending LNCSBs as a substitute for SSBs to aid in weight management.

Substituting LNCSBs for SSBs was associated with a reduction in body mass index (BMI) by 0.32 (95% CI, -0.58 to -0.07).

Practitioners may use BMI changes as an additional metric for assessing the effectiveness of LNCSBs in dietary interventions.

The multi-ingredient supplement (SUPP) resulted in a greater increase in lean body mass (LBM) compared to the placebo (PL) after 10 weeks of resistance exercise training (RET) (SUPP: +4.1 ± 1.3 kg, PL: +2.8 ± 1.7 kg, P < 0.05).

Incorporating a high-quality multi-ingredient supplement may enhance muscle gain during resistance training.

The multi-ingredient supplement (SUPP) increased biceps brachii muscle cross-sectional area (CSA) and thickness compared to the placebo (PL) group.

Using a multi-ingredient supplement may specifically enhance upper-body muscle development.

Postintervention weight change averaged -3.7 ± 9.5%, with greater weight loss in the DSE than the ILI group.

Practitioners should note that weight loss outcomes vary significantly between intervention types.

Diet is a prominent modifiable element driving weight gain and adiposity.

Practitioners should focus on dietary modifications to address obesity.

The intervention group achieved a mean body weight change of −9.5% (±4.1) with 90% of participants losing ≥ 5%.

Practitioners can consider remote interventions as effective for weight loss in older adults.

Remote interventions are feasible for older adults and can support fidelity, adherence, engagement, and clinically significant weight loss.

Practitioners can confidently use remote interventions to promote healthy aging in older adults.

Initial adopters engaged in 108.3 minutes per week more at 1 year compared with early nonadopters (P < .01).

Encouraging early adoption of physical activity can lead to significantly higher activity levels over time.

Failure to achieve PA goals at 2, 3, or 4 months results in less overall PA at 1 year.

Identifying individuals who struggle with early PA goals can help target interventions.

For every pound of weight lost, there was a 0.02-point reduction on the HbA1C measured at the end of the RPM.

Practitioners can use weight loss as a target to help improve HbA1C levels in T2D patients.

Higher protein intake (HP) and moderate protein intake (MP) groups showed greater increases in skeletal muscle mass (SMM) compared to the lower protein intake (LP) group, with increases of 5.1% and 5.4% respectively, versus 2.3% for LP (P < 0.05).

Practitioners should encourage higher protein intake in older women to enhance muscle gains during resistance training.

Protein intake is a moderating variable for body recomposition in older women undergoing resistance training, with low protein intake having a less favorable effect.

Emphasizing adequate protein intake is crucial for optimizing body recomposition in older women engaged in resistance training.

Orforglipron has advanced through Phase 3 clinical development, demonstrating significant reductions in hemoglobin A1c and body weight (up to 7.9%) with favorable tolerability.

Practitioners can consider Orforglipron as an effective option for managing hemoglobin A1c and body weight.