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Semaglutide had substantial effects on multiple secondary alcohol-related and somatic outcomes.

Semaglutide may improve various aspects of health related to alcohol use disorder in addition to reducing drinking.

Semaglutide resulted in a similar reduction in body weight across frailty subgroups.

Semaglutide can be used effectively for weight management in patients with obesity-related HFpEF, regardless of frailty status.

Semaglutide 2.4 mg reduces body weight by an estimated mean change ranging from -9.40% to -16.42% in an East Asian population.

Practitioners can consider semaglutide 2.4 mg as an effective option for weight loss in East Asian adults with obesity.

A 12-week partial meal replacement (PMR) diet is effective for weight loss in overweight or obese patients after ischemic stroke, with 52.9% of participants achieving ≥5% weight loss compared to 11.9% in the standard care group.

Healthcare providers can consider PMR diets as a viable option for weight management in stroke patients.

GLP-1 receptor agonists or co-agonists have demonstrated substantial and sustained weight loss along with notable improvements in cardiometabolic markers.

Practitioners may consider GLP-1 receptor agonists as effective options for weight management and improving cardiometabolic health.

Endoscopic sleeve gastroplasty (ESG) has demonstrated durable weight loss, favorable safety, and superior cost-effectiveness compared to pharmacotherapy alone.

Practitioners may consider ESG as a viable option for patients seeking effective weight loss.

Combination strategies using endoscopic bariatric therapies (EBTs) and anti-obesity medications (AOMs) result in greater total-body weight loss than either modality alone.

Combining EBTs with AOMs may enhance weight loss outcomes for patients.

Semaglutide treatment resulted in significant reductions in body mass index (BMI), waist circumference, and HbA1c.

Practitioners can consider semaglutide as an effective treatment for reducing BMI and improving glycemic control in obese T2DM patients.

Lifestyle modifications can mitigate cancer risk associated with obesity.

Encouraging lifestyle changes can be a key strategy in cancer prevention efforts.

Novel medications such as GLP-1 agonists have demonstrated sustained weight loss in patients with obesity.

Practitioners can consider GLP-1 agonists as a treatment option for obesity.

The FDA authorizes the use of injectable semaglutide for the treatment of obesity.

Practitioners can consider semaglutide as an approved treatment option for obesity in the U.S.

Bariatric surgery is the most effective treatment for patients with Type 2 diabetes mellitus (T2DM) and obesity.

Clinicians should consider bariatric surgery as a primary treatment option for patients with T2DM and obesity.

Metabolic surgery, intensive lifestyle modification, and pharmacologic approaches are viable options for achieving diabetes remission.

Practitioners should consider these options early in the disease course for better outcomes.

A comprehensive approach is the best way to manage weight.

Practitioners should consider a multifaceted approach to obesity treatment.

Comprehensive management of diabetic nephropathy includes lifestyle interventions and medication selection.

Practitioners should implement lifestyle changes alongside medication for effective management.

Dietary adherence, including protein and salt restriction, is relevant in inhibiting progression of chronic kidney disease.

Dietary recommendations should focus on protein and salt restrictions to manage kidney disease progression.

There is moderate evidence for eccentrically biased training to increase quadriceps size in ACL-reconstructed individuals.

Practitioners should consider incorporating eccentrically biased training in rehabilitation programs for ACL-reconstructed patients.

Positive changes in quadriceps size were seen following traditional, eccentrically biased, and blood flow restriction exercise interventions in ACL-reconstructed limbs.

Incorporating these exercise interventions may effectively enhance quadriceps size in ACL rehabilitation.

Exercise is one of the most effective strategies to prevent sarcopenia.

Incorporating exercise into daily routines can significantly help in preventing muscle loss in older adults.

A combination of adequate nutrition and regular exercise is recommended to promote muscle health and function.

Practitioners should encourage both dietary and exercise interventions for optimal muscle health in older adults.

Canagliflozin results in weight loss and reduction of blood pressure.

Incorporating canagliflozin may aid in weight management and blood pressure control for diabetic patients.

The management of MASLD in patients with T2D includes dietary and behavioral management, pharmacological treatment, and bariatric procedures.

Practitioners should consider a comprehensive management approach for diabetic patients with MASLD.

Higher protein diets optimize muscle mass during periods of resistance training, facilitating strength increases.

Athletes should consider higher protein intake to enhance muscle mass and strength.

Creatine monohydrate supplementation enhances strength and power.

Incorporating creatine monohydrate can be beneficial for strength and power training.