Research
Cellular
LCDs and MCDs showed the most consistent metabolic benefits, particularly with combined fat and protein replacements.
Practitioners should consider LCDs and MCDs with mixed macronutrient replacements for optimal metabolic health.
StrongSupportsmedium confidence
LCDs and MCDs showed the most consistent metabolic benefits. Combined fat and protein replacement yielded greater improvements.
Why this rating
Based on the meta-analysis of 149 randomized controlled trials.
Source
Carbohydrate-restricted diet types and macronutrient replacements for metabolic health in adults: A meta-analysis of randomized trials
Shuo Feng et al. · Clinical Nutrition · 2025
Meta-analysisCited 3×
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