Research
Cellular
Dose-dependent effects were more prominent for MASH resolution than fibrosis improvement.
Practitioners should consider the dosage of anti-diabetic agents when aiming for MASH resolution.
StrongSupportsmedium confidence
Dose‐dependent effects led to significant heterogeneity (I2 = 73%)... indicating potential weight‐loss‐independent anti‐fibrotic pathways.
Why this rating
Based on a meta-analysis of five RCTs.
Source
Histological efficacy of anti‐diabetic agents in <scp>MASH</scp> and the mediating role of weight loss: A network meta‐analysis
Mainak Banerjee et al. · Diabetes Obesity and Metabolism · 2025
DOI 10.1111/dom.70187
Meta-analysisCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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