Research
Cellular
Creatine supplementation demonstrated non-significant effects on muscle strength (SMD = 0.03, 95% CI: -0.35, 0.42) but yielded the most pronounced improvement in muscle mass (MD = 2.18, 95% CI: 0.92, 3.44).
Creatine may be beneficial for increasing muscle mass in older adults, but its effect on strength is not significant.
StrongQualifiesmedium confidence
Creatine supplementation demonstrated non-significant effects on muscle strength versus training alone (SMD = 0.03, 95% CI: -0.35,0.42) but yielded the most pronounced improvement in muscle mass (MD = 2.18, 95%CI: 0.92,3.44).
Why this rating
Based on a systematic review and meta-analysis of RCTs.
Source
The impact of nutritional intervention and resistance training on muscle strength and mass in healthy older adults—a comparative analysis
Yong Ma et al. · Frontiers in Nutrition · 2025
DOI 10.3389/fnut.2025.1640858
Meta-analysisCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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