Research
Cellular
HMB supplementation failed to demonstrate significant benefits for muscle strength (SMD = -0.22, 95% CI: -0.57, 0.12) or mass outcomes (MD = 0.05, 95% CI: -0.33, 0.44).
HMB supplementation may not be effective for improving muscle strength or mass in older adults.
StrongRefutesmedium confidence
HMB supplementation critically failing to demonstrate significant benefits for muscle strength (SMD = -0.22, 95%CI: -0.57,0.12) or mass outcomes (MD = 0.05, 95%CI: -0.33,0.44).
Why this rating
Based on a systematic review and meta-analysis of RCTs.
Source
The impact of nutritional intervention and resistance training on muscle strength and mass in healthy older adults—a comparative analysis
Yong Ma et al. · Frontiers in Nutrition · 2025
DOI 10.3389/fnut.2025.1640858
Meta-analysisCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Protein supplementation combined with resistance training significantly enhanced muscle strength (SMD = 0.45, 95% CI: 0.20, 0.69) and muscle mass (MD = 0.37, 95% CI: 0.04, 0.70).Strong
- Creatine supplementation demonstrated non-significant effects on muscle strength (SMD = 0.03, 95% CI: -0.35, 0.42) but yielded the most pronounced improvement in muscle mass (MD = 2.18, 95% CI: 0.92, 3.44).Strong
Related findings · Cellular
- Athletes aiming to reduce fat mass and preserve FFM should consume protein intakes in the range of ∼1.8-2.7 g kg(-1) d(-1).Strong
- A minimum daily protein intake of ≥1.6 g/kg is necessary to observe significant improvements in muscle mass from whey protein supplementation.Strong
- Most athletes ideally need 1.2 to 2.0 grams/kg of body weight/day of protein, preferably split across 3-4 meals.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →