Research
Cellular
There were no significant differences in myofibrillar or sarcoplasmic protein concentrations between high and low anabolic responders before or after the 12-week RET program.
Practitioners should note that muscle protein concentrations may not be a reliable indicator of anabolic response to resistance training.
StrongRefutesmedium confidence
Our data suggest myofibrillar or sarcoplasmic protein concentrations do not differ between HI versus LO anabolic responders prior to or following a 12-week RET program.
Why this rating
The conclusion is based on direct comparisons made in the study.
Source
Peer Review #3 of "Skeletal muscle mitochondrial volume and myozenin-1 protein differences exist between high versus low anabolic responders to resistance training (v0.1)"
Brad J. Schöenfeld · 2018
DOI 10.7287/peerj.5338v0.1/reviews/3
cohort · n=25
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High anabolic responders (HI) showed greater citrate synthase activity compared to low anabolic responders (LO) after 12 weeks of resistance exercise training (RET) with a significant main effect (HI>LO, p=0.018).Strong
- Myozenin-1 protein levels were up-regulated in the low anabolic responders (LO) after 12 weeks of RET.Strong
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