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Cellular
Total thigh muscle volume decreased by 1.7% after 2 days and 5.5% after 7 days of disuse (P<0.001).
Practitioners should be aware that even short periods of disuse can lead to significant muscle loss.
StrongSupportsmedium confidence
In contrast to the control leg total thigh muscle volume had decreased by 1.7 (P<0.01) and 5.5 % (P<0.001) in the immobilized leg after 2 and 7 days of disuse, respectively.
Why this rating
Based on the clear statistical significance and study design.
Source
The impact of short term disuse and dietary protein intake on skeletal muscle mass and protein synthesis rates in humans
Sean P. Kilroe · 2023
DOI 10.26481/dis.20230925sk
other
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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