Mixed
Caloric restriction (CR) is an effective intervention that impacts aging, age-related pathologies, and longevity in model organisms such as mice and rats.
While this paper confirms caloric restriction extends longevity in mice and rats, it does not provide specific human dosing protocols. For humans, this suggests that avoiding overconsumption and maintaining a healthy weight may support healthy aging, but specific restriction protocols should be discussed with a healthcare provider.
In addition, caloric restriction (CR) has also been found to impact aging, age-related pathologies, and longevity in mice and rats.
Why this rating
Supported by multiple citations (Ref 2) in a high-impact review article, though specific human trial data is not detailed in this excerpt.
Source
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Jun Guo et al. · Signal Transduction and Targeted Therapy · 2022
DOI 10.1038/s41392-022-01251-0
More from this paper
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- Mitochondrial dysfunction, specifically the loss of mild depolarization in short-lived mice, contributes to aging by increasing ROS-mediated protein damage.Good
- Epigenetic clocks, such as the DNAm PhenoAge and DunedinPoAm, can predict biological age, lifespan, and risk of chronic disease.Good
Related findings · Mixed
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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