Research
Energy balance
Mitochondrial dysfunction, specifically the loss of mild depolarization in short-lived mice, contributes to aging by increasing ROS-mediated protein damage.
Maintaining mitochondrial health through exercise and healthy metabolism may preserve the 'mild depolarization' state seen in long-lived species, potentially reducing oxidative stress.
GoodSupportsHIGH confidence
This result shows that ROS-mediated protein damage caused by the disappearance of mild depolarization of mitochondria is one of the main causes of aging in short-lived mice, and mild depolarization of mitochondria is crucial to the mitochondrial antiaging system.
Why this rating
Based on specific findings in mice, bats, and naked mole rats.
Source
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Jun Guo et al. · Signal Transduction and Targeted Therapy · 2022
DOI 10.1038/s41392-022-01251-0
narrative_reviewCited 1,557×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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