Research
Mixed
Cellular senescence is a principle causative factor in organismal aging and facilitates aging-associated diseases.
This mechanism explains why aging tissues accumulate damage. Interventions targeting senescent cells (senolytics) are being researched to mitigate age-related diseases, though specific protocols are not detailed in this text.
StrongSupportsVERY_HIGH confidence
Cellular senescence, with major effects on the maintenance of normal tissue homeostasis, as well as pathological conditions, is a principle causative factor in the organismal aging process and facilitates aging and aging-associated diseases.
Why this rating
High-level consensus in the field, cited extensively in the review.
Source
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Jun Guo et al. · Signal Transduction and Targeted Therapy · 2022
DOI 10.1038/s41392-022-01251-0
narrative_reviewCited 1,557×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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