Research
Energy balance
Weight loss is the primary therapy for NAFLD, improving liver biochemistry, histology, and insulin sensitivity.
Lose weight through diet and exercise. This is the most effective way to improve liver health in NAFLD patients, even without medication.
GoodSupportsHIGH confidence
Weight loss is the primary therapy for most patients with NAFLD. Weight loss can improve liver biochemical tests, liver histology, serum insulin levels, and quality of life in patients with NAFLD [65–69].
Why this rating
Supported by multiple studies and meta-analyses cited in the review, though specific trial data is summarized rather than presented raw.
Source
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss
Sjaak Pouwels et al. · BMC Endocrine Disorders · 2022
DOI 10.1186/s12902-022-00980-1
narrative_reviewCited 850×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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