Research
Micronutrients & recovery
Vitamin E supplementation (800 IU/day) significantly reverses steatohepatitis and reduces hepatic steatosis and ALT in non-diabetic patients, but long-term safety concerns exist.
Non-diabetic NAFLD patients may benefit from 800 IU/day Vitamin E to improve liver health, but should be aware of potential long-term risks.
GoodQualifiesHIGH confidence
The PIVENS study showed that a 2-year period of treatment with Vitamin E at 800 IU / day in adult patients significantly reverses steatohepatitis and significantly reduced hepatic steatosis and alanine aminotransferase (ALT), but did not had significant changes in fibrosis compared to placebo [58, 60].
Why this rating
Based on the PIVENS study and meta-analyses cited.
Source
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss
Sjaak Pouwels et al. · BMC Endocrine Disorders · 2022
DOI 10.1186/s12902-022-00980-1
narrative_reviewCited 850×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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