Research
Cellular
T2DM is associated with greater hepatic fat and more subfascial adipose tissue around skeletal muscle compared to non-diabetic individuals.
Recognizing the impact of hepatic and subfascial fat can inform treatment strategies for T2DM.
StrongSupportsmedium confidence
T2DM was associated with greater hepatic fat (P < 0.05), and more subfascial adipose tissue around skeletal muscle (P < 0.05).
Why this rating
Based on imaging assessments of fat distribution in a controlled study.
Source
Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus
Koichiro Azuma et al. · American Journal of Physiology-Endocrinology and Metabolism · 2007
DOI 10.1152/ajpendo.00394.2006
cross-sectional · n=102Cited 78×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Individuals with type 2 diabetes mellitus (T2DM) exhibit more severe insulin resistance (IR) compared to similarly obese non-diabetic individuals, with IR measured at 6.1 +/- 2.3 mg x min(-1) x kg FFM(-1) for T2DM and 9.9 +/- 3.3 mg x min(-1) x kg FFM(-1) for non-DM (P < 0.01).Strong
- T2DM is associated with less leg fat mass (-1.2 +/- 0.4 kg, P < 0.01) and greater trunk fat mass (+1.1 +/- 0.4 kg, P < 0.05) compared to non-diabetic individuals.Strong
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