Research
Neural
Hypothalamic inflammation and gliosis are present in children and adults with obesity.
Practitioners should consider hypothalamic inflammation as a factor in obesity management.
StrongSupportsmedium confidence
Both support the presence of hypothalamic inflammation and gliosis in children and adults with obesity.
Why this rating
The claim is supported by a synthesis of translational data.
Source
The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans
Letícia E. Sewaybricker et al. · Endocrine Reviews · 2022
DOI 10.1210/endrev/bnac023
reviewCited 56×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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