Research
Cellular
The severity of hypothalamic inflammation and gliosis is related to comorbid conditions such as glucose intolerance and insulin resistance.
Understanding these relationships can help in targeting treatment for obesity-related comorbidities.
StrongSupportsmedium confidence
Moreover, the severity of hypothalamic inflammation and gliosis has been related to comorbid conditions, including glucose intolerance, insulin resistance, type 2 diabetes, and low testosterone levels in men, independent of elevated body adiposity.
Why this rating
Supported by human studies and correlational data.
Source
The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans
Letícia E. Sewaybricker et al. · Endocrine Reviews · 2022
DOI 10.1210/endrev/bnac023
reviewCited 56×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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