Research
Neural
Greater hypothalamic inflammation and gliosis may predict adiposity gain and worsening insulin sensitivity.
Monitoring hypothalamic inflammation could be important for predicting weight gain and metabolic decline.
GoodSupportsmedium confidence
Cross-sectional findings are augmented by a small number of prospective studies suggesting that a greater degree of hypothalamic inflammation and gliosis may predict adiposity gain and worsening insulin sensitivity in susceptible individuals.
Why this rating
Supported by prospective studies, though limited in number.
Source
The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans
Letícia E. Sewaybricker et al. · Endocrine Reviews · 2022
reviewCited 56×
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