Research
Cellular
Multi-ingredient protein (MIP) supplements combined with resistance exercise training lead to significant increases in fat-free mass (FFM) by 0.80 kg and improvements in 1-repetition maximum (1RM) lower body strength by 4.22 kg and upper body strength by 2.56 kg compared to non-MIP supplemented conditions.
Practitioners can consider recommending MIP supplements to enhance muscle mass and strength gains in individuals undergoing resistance training.
StrongSupportsmedium confidence
Data from 35 trials with 1387 participants showed significant (p<0.05) increases in FFM (0.80 kg (95% CI 0.44 to 1.15)), 1RM lower body (4.22 kg (95% CI 0.79 to 7.64)) and 1RM upper body (2.56 kg (95% CI 0.79 to 4.33)) where a supplement was compared with all non-MIP supplemented conditions.
Why this rating
Based on a systematic review and meta-analysis of 35 trials.
Source
Do multi-ingredient protein supplements augment resistance training-induced gains in skeletal muscle mass and strength? A systematic review and meta-analysis of 35 trials
Kerry R O’Bryan et al. · British Journal of Sports Medicine · 2019
DOI 10.1136/bjsports-2018-099889
Meta-analysisCited 48×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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