Research
Cellular
Having a 'more coupled' phenotype enables caloric restriction-induced improvements in muscle mitochondrial function.
Individuals with a more efficient mitochondrial coupling may benefit more from caloric restriction.
StrongConditionalmedium confidence
A subgroup analysis according to baseline P/O demonstrated that a higher (vs lower) P/O was associated with notable improvements in ATPmax and P/O after CR.
Why this rating
Based on study design from abstract.
Source
EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS
Lauren M. Sparks et al. · The Journal of Clinical Endocrinology & Metabolism · 2016
DOI 10.1210/jc.2016-3211
rct · n=51Cited 45×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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