Research
Cellular
There is no significant difference in muscle hypertrophy between segments in the placebo group.
Placebo may not be effective for muscle hypertrophy in resistance training contexts.
StrongSupportsmedium confidence
Otherwise, for PLA group there was no significant difference in the magnitude of segmental muscle hypertrophy.
Why this rating
Based on the randomized controlled trial design indicated in the abstract.
Source
Creatine supplementation elicits greater muscle hypertrophy in upper than lower limbs and trunk in resistance-trained men
João Pedro Nunes et al. · Nutrition and Health · 2017
DOI 10.1177/0260106017737013
rct · n=43Cited 28×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Creatine supplementation leads to greater muscle hypertrophy in the upper limbs (7.1 ± 2.9%) compared to lower limbs (3.2 ± 2.1%) and trunk (2.1 ± 2.2%) in resistance-trained young adult men.Strong
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