Research
Cellular
Genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI) predicts an increase in waist circumference after weight loss.
Practitioners should consider genetic predisposition when assessing potential waist circumference changes after weight loss.
StrongSupportsmedium confidence
However, the WHRadjBMI genetic score did predict an increase in waist circumference independent of weight change.
Why this rating
Based on the large sample size from the Look AHEAD study.
Source
Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss
Malene Revsbech Christiansen et al. · Diabetes · 2023
DOI 10.2337/db23-0131
cohort · n=1415Cited 14×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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