Research
Cellular
2 years of 25% calorie restriction significantly reduced TNFα by -0.77 pg/mL compared to -0.38 pg/mL in the ad-libitum group (p=0.025).
Practitioners may consider calorie restriction as a strategy to reduce inflammatory cytokines in healthy adults.
StrongSupportsmedium confidence
The estimated change from baseline to 24 mo was -0.77 vs. -0.38 pg/mL for TNFα (p=0.025 for group effect).
Why this rating
Based on a randomized controlled trial design.
Source
Effects of prolonged calorie restriction on inflammation and immune function: a randomized controlled trial in non‐obese humans (40.4)
Simin Nikbin Meydani et al. · The FASEB Journal · 2014
DOI 10.1096/fasebj.28.1_supplement.40.4
rct · n=218Cited 7×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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