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Muscle health may be maintained when optimal nutrition therapy is provided in complement with early physical rehabilitation in critically ill patients.

Practitioners should consider integrating optimal nutrition with early rehabilitation strategies to support muscle health in critically ill patients.

Acai supplementation promoted faster recovery of knee flexors isometric peak torque (IPT) at 24 and 72 hours compared to placebo.

Incorporating acai supplementation may enhance recovery of knee flexor strength after exercise.

Obesity increases the load on weight-bearing joints, especially the knee and hip.

Practitioners should consider joint health when addressing obesity in patients.

Semaglutide and tirzepatide resolve metabolic dysfunction-associated steatohepatitis (MASH) in 41% and 53% of patients, respectively, without worsening fibrosis after 52-72 weeks.

These medications can significantly improve liver health in adults with MASH.

Efsubaglutide Alfa showed a preferable tolerability and safety profile.

Efsubaglutide Alfa may be a safer option for weight management compared to other treatments.

Muscle mass was reduced only in the control group after immobilization (P < 0.05).

This suggests that omega-3 supplementation may help preserve muscle mass during immobilization.

Muscle fibre activation and subsequent anabolic signalling are independent of load and repetition duration when resistance exercise is performed to task failure.

Practitioners can use lighter loads to task failure for muscle activation without needing heavier weights.

Anabolic resistance contributes to skeletal muscle atrophy with aging and during critical illness.

Practitioners should consider anabolic resistance when developing interventions for muscle preservation in aging and critical care.

Eccentric muscle actions resulted in a greater effect size compared with concentric actions, but results did not reach statistical significance (ES difference = 0.25 ± 0.13; p = 0.076).

Practitioners should consider incorporating both eccentric and concentric training in hypertrophy programs.

There may be a possible advantage for the use of long rest intervals to elicit hypertrophic effects.

Longer rest intervals may be more effective for hypertrophy in trained individuals.

Targeted combinations of medicines with nutrition and lifestyle interventions can increase treatment efficacy and reduce adverse effects.

Integrating nutrition and lifestyle changes with medication may enhance treatment outcomes.

NAFLD is associated with an increased risk of fatal/non-fatal CVD events and other cardiac and arrhythmic complications.

Healthcare providers should consider the cardiovascular risks associated with NAFLD in their patients.

Understanding factors regulating muscle mass is crucial for counteracting muscle loss in clinical settings.

Future research should focus on strategies to prevent muscle loss, especially in older adults.

ALT and AST levels decreased by 14.3% (P = .002) and 18.2% (P < .001) respectively, remaining stable until follow-up 12 weeks after the intervention.

Monitoring liver enzyme levels can help assess the effectiveness of exercise interventions in NAFLD.

A reduction in muscle protein synthesis (MPS) is the main mechanism that underpins lean body mass (LBM) loss early in energy restriction (ER) in adult men.

Practitioners should focus on maintaining MPS to preserve LBM during energy restriction.

There was no change in muscle protein breakdown (MPB) during energy restriction (ER).

MPB does not appear to be affected by short-term energy restriction in this population.

Increases in muscle size are similar irrespective of the time of day at which the training is performed.

Muscle hypertrophy can be achieved regardless of whether training occurs in the morning or evening.

A high body mass index is one of the strongest risk factors for new-onset chronic kidney disease (CKD).

Healthcare providers should monitor kidney health in patients with high BMI.

Leucine has received the most attention among BCAAs for its ability to stimulate the initial acute anabolic response.

Practitioners may consider leucine as a key component in BCAA supplementation for its anabolic properties.

Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D.

Practitioners should consider recommending seafood-derived n-3 fatty acids to potentially lower T2D risk.

EPA, DPA, DHA, and their sum were associated with lower T2D incidence with hazard ratios of 0.92, 0.79, 0.82, and 0.81 respectively.

The specific hazard ratios suggest that increasing levels of these fatty acids may significantly reduce T2D risk.

Age-related loss of muscle mass, strength, and performance, known as sarcopenia, has serious implications for morbidity and mortality.

Understanding the health risks associated with sarcopenia can guide interventions.

Anabolic resistance is implicated in the progression of age-related muscle loss and its complications.

Addressing anabolic resistance may help mitigate muscle loss in aging populations.

Nutrition insecurity is a direct determinant of health.

Practitioners should recognize nutrition insecurity as a critical health factor.