Browse the evidence

Higher doses of caffeine (8 mg • kg -1) increase lactate dehydrogenase (LDH) levels compared to lower doses and placebo.

Higher caffeine doses may lead to increased metabolic stress, which could be beneficial for certain training adaptations.

An 8 mg • kg -1 dosage of caffeine increases uric acid levels compared to placebo.

Practitioners should be aware that higher caffeine intake may elevate uric acid levels, which could have implications for certain individuals.

Changes in chest muscle thickness did not statistically differ between resistance training with 4-6 RPE and 7-9 RPE.

Practitioners may consider that varying proximity to failure in resistance training does not significantly affect muscle thickness outcomes.

The deadlift does not require a longer recovery period than the squat or bench press following high volume training to failure in well-trained men.

Trainers can expect similar recovery times for deadlifts compared to squats and bench presses after high volume training.

Both PBT and ABT strategies produced similar lower body hypertrophy outcomes with no significant group differences.

Both training methods can be effectively used for lower body hypertrophy.

Resistance training with 4-6 RPE and 7-9 RPE produces statistically ambiguous differences in muscle thickness changes at VL50.

Practitioners should consider that varying RPE levels may not lead to significant differences in muscle thickness.

Changes in muscle thickness at VL70 were observed in both RPE groups, with a small between-group effect size.

Both RPE levels can lead to changes in muscle thickness, though the effect size is small.

Trivial between-group effect size was observed for muscle thickness changes at VL50.

The minimal effect size suggests that both training approaches may yield similar outcomes in muscle thickness at VL50.

Resistance training with a 7-9 RPE may elicit marginally greater acute responses of CK and LDH than 4-6 RPE over time.

Practitioners may consider incorporating higher RPE levels to enhance muscle damage responses.

The 7-9 RPE group demonstrated a greater acute response of CK and LDH compared to the 4-6 RPE group.

Higher RPE training may be more effective for inducing muscle damage.

The model coefficient for the interaction of week by time point demonstrates evidence of the repeated bout effect for CK but not LDH.

Understanding the repeated bout effect can help in planning training cycles.

sACE2 decreased significantly on average at 6-months in the diet intervention.

Weight loss interventions may lead to significant decreases in sACE2 levels.

Decrease in sACE2 during a weight loss diet intervention was associated with improvements in fat mass and markers of chronic inflammation.

Weight loss may lead to beneficial changes in inflammation and fat mass through sACE2 modulation.

Serious adverse events were lower in the semaglutide group (13.3%) compared to the placebo group (26.7%) (P < .001).

Semaglutide may offer a safer treatment option for this patient population.

As muscle mass decreases, the risk of conditions like type 2 diabetes rises.

Addressing muscle mass in obesity management could improve health outcomes.

Obesity-related hypertension is a significant contributor to cardiovascular morbidity and mortality.

Healthcare providers should prioritize addressing obesity to mitigate hypertension and related cardiovascular risks.

Übergewicht erhöht die Häufigkeit von Beckenbodenfunktionsstörungen, wobei ein höherer BMI mit einer höheren Prävalenz von Harn- und Stuhlinkontinenz sowie Genitaldeszensus korreliert.

Praktiker sollten Übergewicht als Risikofaktor für Beckenbodenfunktionsstörungen bei Frauen berücksichtigen.

Bei Schwangeren kann Übergewicht das Risiko für postpartale Beckenbodenstörungen deutlich erhöhen.

Praktiker sollten prä- und postpartale Maßnahmen zur Beckenbodengesundheit bei übergewichtigen Schwangeren priorisieren.

Up to 40% of weight loss following treatment with GLP-1RA is accounted for by lean mass.

Clinicians should be aware of potential lean mass loss when prescribing GLP-1RA therapies.

GLP-1 RA use was associated with significantly lower rates of re-tear (RR = 0.699, p < 0.001).

Practitioners may consider GLP-1 RAs as beneficial for reducing re-tear rates in rotator cuff repair patients.

Plant-based protein has differences compared to animal protein that limit its anabolic capacity.

Practitioners should consider the source of protein when advising on muscle maintenance for elderly or vegetarian individuals.

Acute and chronic post-exercise ketosis may stimulate recovery from training.

Practitioners might use ketosis strategies to aid recovery in athletes.

Total thigh muscle volume decreased by 1.7% after 2 days and 5.5% after 7 days of disuse (P<0.001).

Practitioners should be aware that even short periods of disuse can lead to significant muscle loss.

Myofibrillar protein synthesis rates were 36% lower in the immobilized leg compared to the control leg over one week (P<0.001).

Reduced protein synthesis during disuse highlights the importance of maintaining activity to support muscle health.