Browse the evidence

New pharmacological treatments for obstructive sleep apnea (OSA) might be effective.

Practitioners should consider new pharmacological options for treating OSA.

Ten proteins were associated with different rates of weight regain, some specifying pathways of chemotaxis and innate immune responses.

Identifying specific proteins may help tailor interventions for weight regain.

Gut-derived signals significantly modulate outcomes after bariatric surgery.

Understanding gut-derived signals can help in developing interventions for obesity.

High responders to hypertrophic strength training showed a decrease of -10.5% in vastus lateralis cross-sectional area (VLCSA) during detraining.

Practitioners should be aware that high responders may experience significant muscle loss during periods of detraining.

Common cardiovascular conditions, such as heart failure with preserved ejection fraction, can be conceptualized as a consequence of accelerated aging.

Understanding the link between aging and heart failure can guide prevention and management strategies.

Genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI) predicts an increase in waist circumference after weight loss.

Practitioners should consider genetic predisposition when assessing potential waist circumference changes after weight loss.

Remission of diabetes may not be permanent and can result in glycemic relapse over time.

Clinicians should communicate the potential for relapse when discussing remission with patients.

Relevant articles on cardiovascular disease prevention in obesity, atherogenic dyslipidaemia, and chronic kidney disease have been included.

Practitioners should consider the impact of obesity and related conditions on cardiovascular health.

Rapid weight loss induced by semaglutide can lead to noticeable facial volume loss and the appearance of a prematurely aged face, referred to as 'Ozempic face.'

Healthcare providers should be aware of the potential cosmetic implications of semaglutide use for weight loss.

The characteristics of 'Ozempic face' occur in people much younger than what is seen with the natural aging process.

Clinicians should consider age-related factors when assessing patients for semaglutide treatment.

Innovative approaches for nasal delivery of GLP-1 RAs show promising preclinical results.

Practitioners should consider these innovative approaches to enhance the effectiveness of GLP-1 RA delivery.

Intentional weight loss can increase health risk in the long-term due to the release of persistent organic pollutants (POPs) from adipose tissue.

Practitioners should consider the potential long-term health risks associated with weight loss due to POP exposure.

Chronic exposure to low levels of POPs is a new risk factor for common metabolic and cardiovascular diseases.

Awareness of POPs as a risk factor can guide health interventions and weight management strategies.

The release of POPs during weight loss may have harmful effects that are opposite to the expected benefits of losing weight.

Weight loss strategies should consider the potential negative impacts of POP release.

Calculations from oxygen consumption and carbon dioxide production can provide erroneous results when several biochemical pathways are engaged.

Practitioners should be cautious when interpreting energy expenditure calculations, especially when multiple metabolic pathways are involved.

Contemporary antiretroviral therapy (ART) regimens, particularly integrase strand transfer inhibitors (INSTIs) and tenofovir alafenamide (TAF), are contributors to weight gain and obesity in PWH.

Clinicians should consider the impact of specific ART regimens on weight management in PWH.

Bariatric surgery reduces TRL apoB-100 concentration due to reduced production and increased clearance.

Clinicians should consider the impact of bariatric surgery on VLDL particle levels in patient management.

Bariatric surgery reduces TRL apoB-48 concentration due to reduced production.

Healthcare providers should note the reduction in chylomicron levels post-surgery for better patient outcomes.

NAFLD should be understood as part of a systemic disease characterized by abnormal fat accumulation in tissues other than adipose tissue.

Understanding NAFLD as a systemic disease can improve patient management strategies.

There are fundamental biological principles that raise questions about the therapies for obesity.

Practitioners should be aware of the complexities and potential limitations of obesity therapies.

Muscle tissue protein synthesis and breakdown rates range between 1% and 2% across the day in vivo in humans.

Understanding the turnover rates can help in designing effective training and nutrition strategies.

Whey protein supplementation does not accelerate recovery of muscle function following eccentric exercise.

Practitioners should consider that whey protein may not be effective for recovery after eccentric exercise.

Muscle soreness, CK, and CRP showed a transient increase over time with no differences between groups.

Both whey protein and carbohydrates do not significantly affect muscle soreness or inflammation post-exercise.

Novel antidiabetic medications have demonstrated cardiovascular safety and benefits by reducing major adverse cardiac events, improving heart failure, and decreasing CVD-related mortality.

Practitioners should consider novel antidiabetic medications for patients with diabetes and coronary artery disease to improve cardiovascular outcomes.