Browse the evidence

GLP-1 RA users had a higher incidence of delayed wound healing (18.5% versus 7.5%) compared to nonusers.

Practitioners should monitor GLP-1 RA users for delayed wound healing post-surgery.

GLP-1 RA users had lower seroma rates (4.9% versus 14.0%) compared to nonusers.

Practitioners may consider GLP-1 RAs for potentially reducing seroma formation post-surgery.

Over half of patients with type 2 diabetes fail to meet glycemic targets due to clinical inertia.

Practitioners should be aware of the impact of clinical inertia on treatment outcomes.

Microneedle (MN)-based technologies provide a painless drug delivery approach that targets adipose tissue directly, minimizing systemic exposure and reducing the required dosage.

Practitioners may consider MNs as a viable alternative for delivering anti-obesity medications effectively.

Powerlifters exhibited significantly less shoulder extension and horizontal abduction, and hip flexion, extension, and adduction than recreationally strength-trained men.

Powerlifters may need to address limitations in shoulder and hip ROM to optimize performance.

The goal of management in T2D patients with significant fibrosis is to slow the progression of liver disease and reduce associated clinical events.

Clinicians should aim to adapt therapies to manage liver disease progression in diabetic patients.

Periods of unloading lead to a decrease in muscle protein synthesis (MPS) and potentially a transient increase in muscle protein breakdown (MPB).

Avoiding periods of inactivity is important to maintain muscle protein synthesis.

The placebo group and interruption group showed a reduction in power output during the third sprint compared to the maintenance group.

Avoiding interruption of beta-alanine supplementation may be crucial for maintaining sprint performance.

Significant weight loss can lead to aesthetic challenges such as skin laxity.

Practitioners should be aware of potential aesthetic issues in patients after significant weight loss.

Adverse side effects from GLP-1 receptor agonists are mostly gastrointestinal but may also include loss of muscle and bone mass.

Monitor for gastrointestinal side effects and potential muscle and bone mass loss in patients using GLP-1 receptor agonists.

Performing additional sets of resistance exercise does not inherently result in greater increases in muscle size compared to lower volumes.

Practitioners should not assume that increasing the number of sets will always lead to greater muscle growth.

Bariatric surgery is associated with a relatively low number of complications and a reduction in mortality risk.

Bariatric surgery can be considered a safe option with potential mortality benefits.

Chronic alterations in blood pH have a modifiable effect on whole body, muscle, and albumin protein kinetics.

Practitioners should consider the impact of blood pH on protein metabolism in dietary planning.

Leucine oxidation is negatively correlated with blood pH.

Understanding this correlation may help in managing dietary amino acid intake.

DXA-derived lean mass, BIA-derived skeletal muscle mass, and BodPod-derived fat-free mass overestimate D3-Cr-derived skeletal muscle mass.

Practitioners should be cautious of overestimations when using these common body composition assessment methods.

DXA, BIA, and ultrasound-derived appendicular lean mass uniformly underestimate D3-Cr-derived skeletal muscle mass by approximately 2.50 kg.

Practitioners should consider the potential underestimation when using these methods for assessing appendicular lean mass.

Exercise training did not induce further improvements in lean mass in either the supplement or placebo group.

Exercise alone may not be sufficient to increase lean mass in older adults if they are already using effective nutritional supplements.

There are trivial hypertrophic effects between proximal, mid-belly, and distal muscle sites.

Trivial differences in hypertrophy suggest that exercise selection may not need to prioritize specific muscle lengths.

The 'Competition Model of Metabolism' explains stability of physiological states despite metabolic perturbations.

Recognizing the mechanisms behind stability can inform interventions for weight management.

Skeletal muscle pyruvate dehydrogenase activation (PDHa) was 29% lower during the FAT-adpt diet compared to the high-CHO diet.

Lower PDHa activation suggests reduced carbohydrate utilization, which may influence performance strategies.

Skeletal muscle triglycerides (IMTG) were elevated in patients with type 2 diabetes compared to healthy controls and trained athletes.

Increased IMTG levels in type 2 diabetes may indicate altered lipid metabolism that practitioners should consider.

Skeletal muscle pyruvate dehydrogenase activation (PDHa) was 29% lower during high-fat adaptation compared to high-carbohydrate diet.

Lower PDHa activation suggests reduced carbohydrate utilization, which may influence training strategies.

GLP-1 receptor agonists may modify aortic disorders through anti-inflammatory, antioxidant, and antiatherogenic properties.

GLP-1 RAs could be considered for patients with aortic disorders due to their beneficial properties.

Early identification of physical frailty in the liver transplantation clinical pathway is essential for targeted interventions.

Clinicians should implement screening tools for frailty in liver transplant candidates to tailor interventions.