Browse the evidence

Age-related loss of muscle mass, strength, and performance, known as sarcopenia, has serious implications for morbidity and mortality.

Understanding the health risks associated with sarcopenia can guide interventions.

Anabolic resistance is implicated in the progression of age-related muscle loss and its complications.

Addressing anabolic resistance may help mitigate muscle loss in aging populations.

Nutrition insecurity is a direct determinant of health.

Practitioners should recognize nutrition insecurity as a critical health factor.

Lean mass remained stable in some cases, but notable reductions were observed in others, ranging from almost 0% to 40% of total weight reduction.

Clinicians should monitor lean mass changes in patients using semaglutide, as results can vary significantly.

In psoriasis, 4 of 5 clinical studies demonstrated significant improvements in Psoriasis Area Severity Index and weight/body mass index.

GLP-1 receptor agonists may significantly improve psoriasis severity and contribute to weight loss.

Elevated body mass index and weight gain are associated with increased risk of postmenopausal, hormone receptor-positive breast cancer.

Practitioners should consider BMI and weight gain as significant risk factors for breast cancer in postmenopausal women.

Low-grade systemic inflammation is linked to hypercholesterolemia and obesity.

Addressing systemic inflammation may be crucial in managing hypercholesterolemia and obesity.

Regular physical activity boosts host immunity and facilitates a more diverse gut microbiome.

Encouraging regular physical activity can enhance immune function and gut health.

Different fat depots exert different effects on the metabolic profile of individuals.

Practitioners should consider fat depot characteristics in metabolic assessments.

A greater intake of plant fat is associated with a lower risk for overall mortality (HRs, 0.91) and cardiovascular disease (CVD) mortality (HRs, 0.86), particularly from grains and vegetable oils.

Encouraging higher plant fat intake, especially from grains and oils, may benefit longevity.

A higher intake of total animal fat is associated with an increased risk for overall mortality (HRs, 1.16) and CVD mortality (HRs, 1.14).

Reducing animal fat intake may lower mortality risk.

Pharmacologic interventions targeting modifiable cardiometabolic risk factors are a reasonable strategy to prevent CVD development and progression of MASLD.

Practitioners should consider pharmacologic interventions for patients with MASLD to mitigate CVD risk.

The degree of capillarization in muscle is associated with the change in type II fiber CSA following resistance training.

Improving muscle capillarization may enhance the effectiveness of resistance training.

Obesity is a significant predisposing factor for heart failure with preserved ejection fraction (HFpEF).

Practitioners should consider obesity as a critical factor in managing patients with HFpEF.

Muscle size increases vary across regions within and between muscles after resistance training programs.

Practitioners should consider regional differences in muscle hypertrophy when designing training programs.

Muscle architectural changes after resistance and stretch training programs are region-specific.

Training programs should account for region-specific changes in muscle architecture.

Probiotics and prebiotics support gut health and immune function, which are integral to effective recovery.

Including probiotics and prebiotics in recovery nutrition can enhance gut health and immune function.

Weight gain plays an important role in the pathogenesis of obstructive sleep apnea.

Weight management strategies should be emphasized in the treatment of obstructive sleep apnea.

MyoPS increased above REST in both untrained and trained states, with a greater increase in males.

Males may experience a greater increase in muscle protein synthesis following resistance training.

Obesity is associated with and likely has a direct causal role in the onset, progression and severity of chronic kidney disease.

Practitioners should consider the impact of obesity on chronic kidney disease management.

Semaglutide improved physical quality of life by 3.75 points on the SF-36v2.

Semaglutide may enhance physical quality of life for patients in this group.

GLP-1RA users had a lower risk of all-cause mortality (HR, 0.70; 95% CI, 0.63-0.78) compared to other antidiabetic drug users.

Practitioners may consider GLP-1RAs as a treatment option for reducing all-cause mortality in this population.

Obesity is a leading risk factor for cardiovascular disease (CVD).

Clinicians should prioritize addressing obesity to mitigate CVD risks.

Multidomain lifestyle intervention may slow biological aging long term, as captured by an FI-E.

Practitioners may consider recommending multidomain lifestyle interventions to promote long-term health benefits.