Browse the evidence

Acute administration of 0839 and 0833 dose-dependently reduced food intake in normal weight rats.

Both 0839 and 0833 may be effective in reducing food intake in normal weight populations.

46% of the 104 studies analyzed lacked information on the proportion of older individuals.

Practitioners should be cautious about the applicability of findings to older patients.

Older patients were mostly underrepresented in clinical trials of GLP-1 receptor agonists and SGLT2 inhibitors.

Clinical guidelines may need to consider the lack of data on older patients.

The 1998 overweight and obesity clinical guidelines defined overweight as a BMI of 25–29.9 kg/m2 and obesity as a BMI of ≥30 kg/m2.

Practitioners should use these definitions for assessing and managing weight status.

Up to half of patients discontinue obesity medications within 1 to 2 years due to various reasons.

Practitioners should be aware of high discontinuation rates and address barriers to adherence.

Further long-term, randomized, double-blind clinical trials are needed to confirm the efficacy and safety of tirzepatide.

Clinicians should be aware that more research is needed before fully endorsing tirzepatide as a treatment.

Future research should prioritize mechanistic human studies, real-world cardiovascular outcomes, and equity in drug access.

Practitioners and researchers should advocate for studies that address these areas to improve understanding and access to treatments.

In 2022, over 890 million adults were living with obesity, representing 43% of adults aged 18 years and over.

Health practitioners should recognize the significant prevalence of obesity in adult populations.

Inhibiting GC does not lead to reductions in food intake or lean mass.

This indicates that GC inhibition could be a safer alternative to current treatments that suppress appetite.

No effects of protein supplementation were observed on muscle volume, muscle strength, or return to sport (RTS).

Protein supplementation may not be beneficial during early rehabilitation for muscle strain injuries.

Further studies with larger samples and long-term follow-up are needed.

Encourage ongoing research to validate and refine strength training protocols for this population.

Dieting-induced weight loss does not reduce mortality or cardiovascular events in obese persons.

Practitioners should be cautious in promoting dieting as a means to reduce mortality or cardiovascular risks.

Knowledge about nutrition and food components was not affected by the nutrition consultations.

Practitioners should note that while eating behavior improves, nutrition knowledge may not change significantly.

The mortality of German T2D patients enrolled in the Disease Management Program (DMP) is 2.4 times higher than that of the general population.

Practitioners should consider the elevated mortality risk for T2D patients in the DMP when planning care.

There were no beneficial effects in terms of risks for cardiovascular disease or mortality associated with aspirin treatment in T2D patients with no established cardiovascular disease.

Aspirin should be used more restrictively for primary prevention in T2D patients.

Obesity rates have climbed to 58% of the adult population across OECD countries.

Health professionals should be aware of the high prevalence of obesity in OECD countries.

Every dollar spent on preventing obesity generates an economic return of up to six dollars.

Investing in obesity prevention can yield significant economic returns, encouraging policymakers to act.

Obesity affects 28% of adults and 7% of children aged 5-17 years in Australia.

Clinicians should be aware of the significant prevalence of obesity in their patient populations.

Langzeituntersuchungen ergaben keine belegbare Uberlegenheit der Verhaltenstherapie.

Langfristige Wirksamkeit der Verhaltenstherapie ist fraglich.

The Shape intervention cost an average of US $758 per participant.

Practitioners can expect the intervention to have a specific cost per participant.

Das Programm ist aufgrund tiefer Gruppentarife der Krankenversicherer in der Schweiz für Anbieter nicht kostendeckend.

Anbieter sollten die wirtschaftlichen Aspekte des Programms berücksichtigen.

Das Programm ist aufgrund tiefer Gruppentarife der Krankenversicherer in der Schweiz für Anbieter nicht kostendeckend.

Anbieter sollten die wirtschaftlichen Aspekte des Programms berücksichtigen.

Participants expressed a strong social identity and belongingness to online zero-carb communities.

Encouraging community support may enhance adherence to zero-carb diets.

The intervention did not result in significant changes in lifestyle behaviors or weight at 6 months.

There is a need for more intensive interventions to achieve significant lifestyle changes.