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Patients experienced an average weight loss of 16.06 ± 7.6 pounds at 12 weeks and 38.82 ± 11.4 pounds at 24 weeks.

Practitioners can expect significant weight loss in patients using compounded GLP-1 ± GIP agonists.

Several newer anti-obesity medications (AOMs) have been shown to reduce body weight significantly.

Clinicians can consider newer AOMs as effective options for weight management in obese patients.

The addition of 500 kcal·d −1 from whole foods/snacks in combination with a rigorous resistance training program promotes a weight gain of ~0.22 kg·wk −1, primarily as lean body mass, over 10 weeks in both male and female athletes.

Athletes looking to gain weight should consider increasing their caloric intake by 500 kcal·d −1 along with a structured resistance training program.

The peanut-based whole foods/snacks group gained less total body mass compared to the high-carbohydrate, peanut-free snack group.

Athletes may need to consider the type of snacks they consume for optimal weight gain results.

35% of protein supplement users take them for muscle mass increase.

Practitioners should emphasize muscle gain in discussions about protein supplementation.

Carbohydrate intake was below the recommended range for power athletes at each timepoint.

Athletes should increase carbohydrate intake to meet performance needs.

A very low-energy diet is an effective method for achieving glycaemic control and weight loss.

Implementing very low-energy diets may benefit patients with diabetes and obesity preoperatively.

Bariatric-metabolic procedures can improve and induce remission of diabetes mellitus.

Consider bariatric-metabolic procedures as a treatment option for patients with diabetes.

The RESTART trial aims to evaluate whether a complex lifestyle intervention can improve and maintain cardiorespiratory fitness, muscle strength, and body composition among older adults with elevated cardiometabolic risk.

Practitioners can consider implementing complex lifestyle interventions to improve fitness and health in older adults at risk.

Secondary and tertiary outcomes include parameters such as muscle strength, physical activity levels, body composition, and health-related quality of life.

Practitioners should consider these additional outcomes when evaluating the impact of lifestyle interventions.

Weight decreases of 1.0% to 2.9%, 3.0% to 4.9%, and 5.0% or greater are associated with a lower risk of type 2 diabetes by 16%, 25%, and 26%, respectively.

Encouraging weight loss can significantly reduce the risk of developing type 2 diabetes.

Preventing weight gain and reducing weight are important for lowering the risk of type 2 diabetes in individuals with a BMI of 22 or greater.

Healthcare providers should focus on weight management strategies for individuals at risk of type 2 diabetes.

Mean weight loss among patients taking liraglutide for at least 3 months was 7.6 kg (7.9%).

Liraglutide can be an effective part of a weight management plan for patients with obesity.

Patients treated for more than 6 months lost significantly more weight (8.6 kg) compared to those treated for less than 6 months (6.2 kg).

Longer treatment with liraglutide may lead to greater weight loss.

Liraglutide, along with lifestyle intervention, is a good option for weight management in the majority of patients with obesity.

Integrating liraglutide with lifestyle changes can improve weight management outcomes.

Superset training reduces session duration by approximately 50% compared to traditional resistance training.

Practitioners can recommend superset training as a time-efficient alternative to traditional resistance training.

Weight loss produces a significant reduction in cardiovascular risk factors and improvements in self-esteem and function.

Encouraging weight loss can lead to improved health outcomes for patients.

Moderate weight loss (5 to 10%) can cause significant improvements in conditions like type 2 diabetes, hypertension, and cardiovascular disease.

Practitioners should aim for moderate weight loss in patients to improve health outcomes.

Good quality cardiac rehabilitation with dietary advice is vital for managing heart attack patients.

Practitioners should incorporate dietary advice as a core component of cardiac rehabilitation programs.

A whole-diet approach is necessary to reduce cardiovascular disease (CVD) risk.

Dietary recommendations should emphasize overall dietary patterns rather than individual foods.

The traditional Mediterranean diet is consistently recommended for lower CVD risk.

Healthcare providers should recommend the Mediterranean diet as part of CVD risk reduction strategies.

A 15-week clinic-based weight loss program improved physical functioning by 6.2 ± 2.9 (p = 0.02; d = 0.31) in cancer survivors compared to a waitlist control group.

Clinicians can consider implementing clinic-based weight loss programs to enhance physical functioning in cancer survivors.

Having three or more visits with the MWLP provider was associated with successful loss of at least 5% of baseline weight.

Frequent engagement with healthcare providers may improve weight loss outcomes.

Home-based exercise may improve aerobic fitness (SMD = 0.42) in older adults.

Home-based exercise can be recommended to improve aerobic fitness in older adults.