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Meal replacements (MRs) led to a greater reduction in body weight by -1.38 kg compared to conventional food-based weight loss diets.

Incorporating meal replacements can be an effective strategy for weight loss in individuals at risk of metabolic syndrome.

MRs resulted in a reduction in body mass index (BMI) by -0.56 kg/m2 compared to conventional diets.

Using meal replacements can help reduce BMI in at-risk populations.

The mean change in body weight was -10.5% with semaglutide and -2.0% with placebo.

Semaglutide may lead to significant weight loss in patients with MASH.

Participation in high-intensity programs for 6 months can lead to weight loss of up to 8 kg (8% of weight) and improvements in cardiovascular disease risk factors and quality of life.

Clinicians should recommend high-intensity lifestyle modification programs for effective weight loss.

To prevent weight regain, participation in weight-loss-maintenance programs for 1 year with at least monthly counseling is recommended.

Clinicians should implement long-term maintenance strategies to support weight loss sustainability.

High levels of physical activity, frequent monitoring of body weight, and consumption of a reduced-calorie diet are associated with long-term weight loss.

Encourage patients to maintain high physical activity and monitor their weight regularly for effective weight management.

Intensive lifestyle modification decreased the incidence of diabetes by 6.2 cases per 100 person-years during a 3-year period.

Encouraging lifestyle changes can significantly reduce the risk of developing diabetes.

Treatment with once-weekly injectable semaglutide resulted in a mean change in body weight of -13.7% compared to -3.2% with placebo (P<0.001).

Semaglutide may be an effective treatment for weight loss in obese individuals with knee osteoarthritis.

Higher weight loss was associated with a lower hazard of discontinuation for both patients with and without type 2 diabetes.

Encouraging weight loss may improve adherence to GLP-1 RA therapy.

Participants in the highest category for total whole grain consumption had a 29% lower rate of type 2 diabetes compared with those in the lowest category.

Encouraging higher whole grain consumption can be an effective strategy for reducing the risk of type 2 diabetes.

Pooled hazard ratios for type 2 diabetes were 0.81 for whole grain cold breakfast cereal and 0.79 for dark bread when comparing those consuming one or more servings a day to those consuming less than one serving a month.

Incorporating whole grain cold breakfast cereal and dark bread into the diet may significantly lower diabetes risk.

Increased physical activity was the most consistent positive correlate of weight loss maintenance.

Practitioners should emphasize the importance of physical activity in weight loss maintenance strategies.

The review identified 51 weight loss and maintenance strategies grouped in 14 domains.

Practitioners can utilize these identified strategies to enhance weight loss maintenance programs.

Fish with higher amounts of ω-3 fatty acids are associated with a lower risk of CVD.

Encouraging the consumption of oily fish rich in ω-3 fatty acids may be beneficial for patients at risk of CVD.

Substitution of low- and no-calorie sweetened beverages (LNCSBs) for sugar-sweetened beverages (SSBs) was associated with a reduction in body weight by 1.06 kg.

Practitioners may consider recommending LNCSBs as a substitute for SSBs to aid in weight management.

Substitution of LNCSBs for SSBs was associated with a reduction in body mass index (BMI) by 0.32.

Practitioners may use LNCSBs to help reduce BMI in at-risk populations.

Participants with OSA and type 2 diabetes mellitus receiving intensive lifestyle intervention (ILI) for weight loss had reduced OSA severity at 10 years.

Practitioners should consider ILI as an effective long-term strategy for managing OSA severity in patients with type 2 diabetes.

OSA remission at 10 years was more common with ILI (34.4%) than DSE (22.2%).

ILI may be a more effective approach for achieving OSA remission in this population.

After 2 years, lifestyle interventions can facilitate weight loss that equates to ~5%.

Practitioners can expect approximately 5% weight loss from lifestyle interventions over two years.

A multifactorial maintenance program is imperative to mitigate weight regain.

Implementing a comprehensive maintenance program is crucial for long-term weight management.

Nutritionally inadequate dietary intake is a leading contributor to chronic cardiometabolic diseases.

Practitioners should focus on improving dietary intake to prevent chronic diseases.

Bariatric surgery results in a mean weight loss of −22.68 kg compared to GLP-1 receptor agonists.

Bariatric surgery may be more effective than GLP-1 receptor agonists for significant weight loss.

Among meta-analyses, 4/5 with critically low quality showed low-carbohydrate diet superiority for weight loss (0.7-4.0 kg).

Low-carbohydrate diets may lead to significant weight loss, but caution is needed due to the quality of the evidence.

Individualized lifestyle interventions reduced the mean difference in BMI by -0.63 kg/m2 compared to control groups.

Practitioners can consider individualized lifestyle interventions as a method for weight management in SMI patients.