Browse the evidence

Atherosclerotic cardiovascular disease risk is highest among South Asian and Filipino adults but lowest among Chinese, Japanese, and Korean adults.

Targeted interventions may be necessary for South Asian and Filipino populations to address higher cardiovascular risks.

Greater numbers of participants correlated with smaller differences in weight loss.

Larger studies may yield more conservative estimates of diet effectiveness.

The mean effect of individualized lifestyle interventions for weight reduction in people with SMI is statistically significant but clinically insignificant.

Practitioners should be aware that while interventions may show statistical benefits, the practical impact on weight may be limited.

No difference was found between RTF and RTNF on maximal strength in overall analysis (SMD: -0.08; p = 0.642).

Both training methods may be equally effective for improving maximal strength.

Higher genetically determined BMI is not associated with insulin secretion.

This suggests that BMI may not directly influence insulin secretion, which could inform treatment approaches.

Significant disproportionality for semaglutide remained in patients with coreported use of antidepressants and benzodiazepines.

Clinicians should consider the interaction of semaglutide with antidepressants and benzodiazepines when assessing risk.

Randomised controlled trials have not provided conclusive evidence that physical activity started during adulthood extends lifespan.

Caution should be exercised in claiming lifespan benefits from adult physical activity alone.

The health-related benefits of exercise have not yet translated into a proven causal relationship with longevity.

While exercise is beneficial, its direct impact on longevity remains unproven.

Obesity prevalence is projected to grow by 40% in the next decade.

Practitioners should prepare for increased obesity-related health issues in the coming decade.

The incidence of obesity-related glomerulopathy has increased tenfold in recent years.

Clinicians should be aware of the rising rates of kidney issues related to obesity.

Ninety-four percent of full service meals and seventy-two percent of fast food meals contained at least 600 kcal.

Practitioners should be aware that many restaurant meals are high in calories, impacting dietary recommendations.

The national penny-per-ounce sugar-sweetened beverage (SSB) tax was highly cost-saving from health care and societal perspectives.

Implementing an SSB tax could lead to significant cost savings in health care.

Incremental cost-effectiveness ratios for the SSB tax ranged from $20,247 to $42,662 per quality-adjusted life year for 100% price pass-through.

The SSB tax could be a cost-effective public health intervention.

The SSB tax positively affected both tax revenues and health care cost savings for the government.

The SSB tax could enhance government revenue while reducing health care costs.

The adjusted hazard ratios for the highest tertile of achieved plasma levels were 0.98 for EPA and 1.02 for DHA.

The lack of significant hazard ratios suggests that high levels of EPA and DHA do not alter cardiovascular risk in this population.

Late reoperation was significantly higher after gastric banding compared with gastric bypass (31.4% vs. 8.1%, P < 0.01).

Gastric banding may carry a higher risk of needing reoperation compared to gastric bypass.

Amino acids supplementation results are equivocal and are not warranted.

Athletes may not benefit from amino acid supplements as much as from protein supplements.

The food industry plays a significant role in funding nutrition research.

Practitioners should be aware of the influence of food industry funding on nutrition research.

The CDC has recommended actions to manage conflicts of interest in nutrition research.

Practitioners should consider CDC recommendations when evaluating nutrition research.

To achieve nondominance, the annual price of semaglutide would need to be reduced from $13,618 to $3,591.

This suggests that pricing strategies for semaglutide could significantly impact its adoption in clinical practice.

Liraglutide has some common adverse effects, although generally not serious ones.

Practitioners should be aware of potential side effects when prescribing liraglutide.

Obesity has tripled in the last 10 years, killing approximately 28 million people each year.

Health practitioners should be aware of the growing obesity epidemic and its significant mortality impact.

There was no overall pooled effect on HbA1c in favor of restricting carbohydrate.

Carbohydrate restriction may not significantly improve glycaemic control in Type 2 diabetes.

The implementation of MTMs could potentially lead to net cost savings of $13.6 billion annually from a health care perspective.

Expanding coverage for MTMs could be a financially beneficial policy for healthcare systems.