Browse the evidence

Cardiovascular disease (CVD) is the leading cause of death in China, accounting for 36% of deaths.

Healthcare strategies in China should prioritize addressing CVD to reduce mortality.

No significant associations were found between LCD scores and mortality risk in other racial and ethnic groups.

Practitioners should be aware that LCD scores may not be relevant for mortality risk in non-Hispanic populations.

Despite extensive research, many unknowns remain in the field of nutrition due to the difficulty of studying lifestyle factors in isolation.

Practitioners should remain aware of the complexities and uncertainties in nutrition research.

Mitochondrial dysfunction, specifically the loss of mild depolarization in short-lived mice, contributes to aging by increasing ROS-mediated protein damage.

Maintaining mitochondrial health through exercise and healthy metabolism may preserve the 'mild depolarization' state seen in long-lived species, potentially reducing oxidative stress.

Adherence to a healthful plant-based diet (hPDI) is associated with lower risk of obesity and less weight gain, whereas adherence to an unhealthful plant-based diet (uPDI) is associated with higher risk of obesity and more weight gain.

To manage weight, focus on the quality of your plant foods. Prioritize whole grains, fruits, vegetables, nuts, and legumes (healthful plant foods) while limiting refined grains and added sugars (unhealthful plant foods). Simply being vegetarian is not enough; the quality of the plants matters significantly for preventing obesity.

High-intensity sprint training can reduce abdominal fat tissue more effectively than moderate-intensity aerobic training with similar energy expenditure.

If you have time constraints or want to target abdominal fat, consider incorporating high-intensity sprint training. It may be more effective for abdominal fat loss than moderate-intensity exercise, even if you burn the same number of calories.

Inpatient very-low-calorie diet (VLCD) at 5 kcal/kg/day for approximately 20 weeks significantly reduces liver size and abdominal adipose tissue, thereby minimizing surgical risks and enabling successful bariatric surgery in patients with extreme obesity (BMI ≥ 50 kg/m²).

If you have extreme obesity (BMI 50+), standard dieting often fails to reduce surgical risks enough for safe operation. This protocol suggests a supervised, inpatient very-low-calorie diet (5 kcal/kg/day) for about 20 weeks. This drastic measure shrinks the liver and fat, making surgery much safer, even without exercise or drugs. It is a high-commitment bridge to a life-changing surgery.

High-Intensity Interval Training (HIIT) performed for 7 weeks leads to significant long-term reductions in body mass, fat mass, and visceral fat area in women with overweight/obesity, even two years after the intervention ends, whereas Time-Restricted Eating (TRE) alone does not significantly reduce these metrics compared to baseline in the long term.

For women with overweight or obesity, incorporating High-Intensity Interval Training (HIIT) into your routine, even just 3 times a week, can lead to significant, lasting reductions in body fat and visceral fat, even two years after you stop supervised training. While Time-Restricted Eating helps with habit formation, it may not be enough on its own for significant fat loss; combining it with HIIT or focusing on HIIT yields better long-term body composition results.

Elite football players should consume 6-8g of carbohydrates per kg of body weight on match days and 48-72 hours between matches to maximize muscle and liver glycogen stores and prevent performance-depleting fatigue.

On match days, aim for 6-8 grams of carbohydrates for every kilogram of your body weight. If you have matches close together (every few days), maintain this high intake for 48-72 hours between games. To avoid stomach issues, use sports drinks or gels rather than trying to force down huge amounts of solid food right before kickoff.

Post-match carbohydrate intake of ~1g/kg body weight per hour for 4 hours is required to maximize glycogen resynthesis and recovery speed.

After a match, eat carbohydrates at a rate of 1 gram per kilogram of body weight every hour for the next 4 hours. If you aren't hungry, drink your carbs using sports drinks or recovery shakes to ensure your muscles refill their energy stores for the next session.

Dehydration of 2% body weight loss impairs football performance, and players should aim to prevent this loss by consuming 5-7ml/kg of fluid 2-4 hours before the match.

To avoid performance drops, do not lose more than 2% of your body weight through sweat. Start hydrating 2-4 hours before kickoff by drinking 5-7ml of water for every kg of your body weight. Check your urine color; it should be light yellow. If it's dark, drink more.

Ultra-marathon runners should consume 40-70 kcal/kg/day of energy and 5-8 g/kg/day of carbohydrates during training to maintain energy balance and support high-volume adaptation.

If you are training for an ultra-marathon, you need to eat significantly more than you think. Aim for 40-70 calories per kilogram of body weight every day, and ensure 5-8 grams of carbohydrates per kilogram. This is not optional; it is required to support your training volume and prevent injury or illness. Use liquid calories and energy-dense foods to manage the volume.

Measuring Resting Metabolic Rate (RMR) and adjusting caloric goals based on weight loss-induced metabolic adaptations prevents weight loss plateaus and optimizes energy balance.

If you are not losing weight despite following a standard diet, your metabolism may have adapted. Get your Resting Metabolic Rate (RMR) tested using a portable device or metabolic cart. Use this number to calculate a personalized calorie goal that creates a deficit relative to YOUR specific energy needs, not a generic number. Re-test as you lose weight to adjust your plan.

85.6% of powerlifters reported paying specific attention to nutrition practices in the pre-exercise period by ingesting more carbohydrate rich foods.

Practitioners should emphasize carbohydrate intake before training for optimal performance.

80% of powerlifters reported paying attention to postexercise nutrition, primarily ingesting more protein rich foods.

Advise powerlifters to prioritize protein intake after training for optimal recovery.

Long-term low caloric deficit diets (20-28 weeks) with high protein and carbohydrate diets are main strategies in the precontest phase.

Bodybuilders should adopt a structured approach to dieting over several months leading up to competitions.

A high-carbohydrate diet (50-70% of energy) improves endurance performance, sprint speed, and recovery compared to low-carbohydrate diets by maximizing muscle glycogen stores.

If you are an endurance athlete (runner or cyclist), ensure 50-70% of your daily calories come from carbohydrates. This maximizes muscle glycogen, which is critical for maintaining intensity, delaying fatigue, and improving race times. Focus on foods with low to moderate glycemic indices.

Addressing overweight and obesity is a primary strategy for reducing the risk of CHD development and progression.

Maintain a healthy weight through a balanced diet and regular moderate exercise. In regions with specific dietary habits (like high carbohydrate intake), focusing on increasing vegetable and fruit consumption and reducing refined carbs is key to lowering heart disease risk.

Weight loss of 10-15% in patients with obesity and Type 2 Diabetes has disease-modifying effects, including improved glycaemic control, reduced need for medication, and potential disease remission.

For patients with obesity and Type 2 Diabetes, aim for a weight loss of 10-15% of body weight. This level of loss is not just for appearance but can modify the disease course, potentially leading to remission and reduced medication needs. This is particularly important for those with higher BMI.

Adding GLP-1 receptor agonists (GLP1RAs) to metformin effectively improves anthropometric measures (weight, BMI, waist circumference, waist-to-hip ratio) in women with PCOS.

For PCOS patients struggling with weight, adding a GLP-1 receptor agonist (like semaglutide or liraglutide) to metformin is a highly effective strategy for reducing body weight and waist circumference, addressing the core metabolic driver of the syndrome.

A 9-month intensive lifestyle intervention (dietary modification and increased physical activity) produces significant short-term weight loss and improved glycemic control in young women with prior gestational diabetes and newly diagnosed type 2 diabetes, with weight loss effects persisting for at least 6 years.

If you are a young woman with a history of gestational diabetes who has recently been diagnosed with type 2 diabetes, committing to a structured 9-month lifestyle program can help you lose about 4% of your body weight and improve your blood sugar control. Key steps include reducing daily calorie intake by roughly 200-240 calories, limiting fat to less than 30% of your diet, eating 20-30g of fiber daily, and exercising moderately for 30 minutes every day. Even after the program ends, the weight loss benefit can last for at least 6 years, though blood sugar control may require ongoing attention.

Combining dietary caloric restriction with exercise yields greater fat loss and lean mass preservation than diet or exercise alone in PCOS.

To lose fat and keep muscle in PCOS, do not rely on exercise alone. Create a modest calorie deficit (500-750 kcal/day) and engage in 150-300 minutes of moderate exercise or 75-150 minutes of vigorous exercise weekly, plus two days of resistance training. This combination is superior to either method in isolation.

Time-restricted eating (TRE) is currently the most prevalent and hottest research topic for obesity intervention, showing equivalent weight loss to continuous energy restriction while offering better long-term adherence.

If you are struggling to stick to a diet, try Time-Restricted Eating (TRE). Instead of counting every calorie all day, restrict your eating to a specific window (e.g., 8 hours) and fast for the rest. Research suggests this is just as effective for weight loss as traditional dieting but easier to stick to long-term because it simplifies decision-making and may improve adherence.

Beta-alanine supplementation (3-6 g/day for 4-8 weeks) delays fatigue in weightlifting by increasing muscle carnosine levels and buffering acidosis.

Take 3-6 grams of beta-alanine daily for at least 4 weeks to build up muscle carnosine. Split the dose (e.g., 2 grams twice a day) to avoid the harmless tingling sensation.