Browse the evidence

Dietary glycemic index does not influence the adaptation of resting energy expenditure during weight loss.

Practitioners should note that dietary glycemic index may not be a significant factor in managing resting energy expenditure during weight loss.

Measured resting energy expenditure (mREE) was significantly lower than predicted resting energy expenditure (pREE) at both 12 weeks and 17 weeks.

This indicates that weight loss leads to a significant decrease in energy expenditure, which should be considered in weight management strategies.

Up to 33% of the weight lost on GLP-1 RAs may be lean tissue mass.

Practitioners should monitor body composition changes in patients using GLP-1 RAs.

GLP-1RAs may raise safety concerns related to weight loss and altered glucose regulation in ALS.

Monitoring for weight loss and glucose regulation is essential when considering GLP-1RAs for ALS.

Excess visceral abdominal fat (EVAF) can occur in people living with HIV-1 even with normal or mildly elevated body mass index (BMI).

Healthcare providers should assess visceral fat in PLWH regardless of BMI.

Hemoglobin A1c decreased across all groups but remained consistently higher in NHB and H compared with NHW at 24 months.

Monitoring of Hemoglobin A1c levels should be tailored based on race and ethnicity post-surgery.

Perturbations in cardiac energy metabolism are a major contributor to diabetes-related cardiovascular disease.

Addressing cardiac energy metabolism may be crucial in managing cardiovascular disease in T2D patients.

Non-responders to the PF regimen demonstrated only transient and limited metabolic shifts.

Understanding the differences in metabolic responses can guide dietary strategies for T2D management.

A shift towards reduced carbohydrate intake and increased dietary fat may be linked to higher morbidity and mortality rates in patients with diabetes.

Practitioners should consider the implications of dietary fat and carbohydrate ratios in diabetes management.

The majority of animal studies demonstrated a greater impact from high-fat diets compared with higher-sugar diets.

Animal studies suggest that high-fat diets may pose greater risks than high-sugar diets, informing dietary recommendations.

A plant-based diet is associated with an increased risk of higher TyG in women (OR = 1.25 for PDI and OR = 1.55 for hPDI).

Practitioners should be cautious about recommending high plant-based diets for women without considering overall dietary balance.

Mathematical models provide insights into the drivers of the obesity epidemic and how metabolism adapts to different diets.

Practitioners can utilize mathematical models to better understand obesity and dietary impacts on metabolism.

Pre-exercise ingestion alters metabolic response by increasing insulin concentration and decreasing plasma glucose concentration, but does not affect exercise tolerance.

Practitioners should be aware that while pre-exercise meals can alter metabolic responses, they do not necessarily improve exercise performance in cardiac rehabilitation patients.

Short-term adaptation to a high-fat diet does not alter glucose tolerance in highly-trained individuals.

Practitioners should note that a high-fat diet may not improve glucose tolerance in endurance athletes.

A 1-3-day high-fat, low-carbohydrate diet impairs performance due to depletion of muscle glycogen stores without significantly changing fat utilisation.

Athletes should be cautious with short-term high-fat, low-carbohydrate diets as they may impair performance.

Fat adaptation does not clearly enhance athletic performance despite changes in fuel metabolism during submaximal exercise.

Athletes may not see performance benefits from fat adaptation despite metabolic changes.

Physiological adaptation from a low- to high-carbohydrate diet may require many weeks.

Practitioners should consider that dietary transitions may not yield immediate metabolic changes.

Individuals with insulin resistance (IR) have higher levels of de novo lipogenesis fatty acids (16:0: 22.9% vs 21.7% and 16:1n7: 1.8% vs 1.3%) and lower levels of omega-6 fatty acids (18:2n6: 30.8% vs 32.5%) compared to insulin sensitive (IS) individuals.

Practitioners should consider fatty acid profiles when assessing insulin resistance in overweight individuals.

There was no significant effect of diet on change in resting metabolic rate (RMR) after accounting for the decreases in body fat and fat free mass (FFM) at any time point.

Dietary glycemic load does not significantly affect resting metabolic rate during caloric restriction.

Physiological adaptation from a low- to high-carbohydrate diet may require many weeks.

Practitioners should consider the time required for metabolic adaptation when advising dietary transitions.

The symposium will showcase advances in nutritional modulation of aging relevant to human health.

Practitioners can stay informed about the latest research in nutrition and aging.

Over 700 million people worldwide suffer from obesity, which is directly or indirectly responsible for about 7% of all deaths.

Healthcare practitioners should recognize the widespread impact of obesity on public health.

Bariatric surgery is recommended for the treatment of type 2 diabetes in extreme cases.

Consider bariatric surgery for patients with severe diabetes who do not respond to other treatments.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is very common in individuals with type 2 diabetes.

Healthcare providers should be aware of the high prevalence of MASLD in their diabetic patients.