Browse the evidence

Longer rest interval lengths (RILs) have a small positive effect on repetition performance, allowing for more repetitions compared to shorter durations.

Practitioners should consider longer rest intervals to enhance performance in lower-body exercises.

Blood lactate levels are slightly higher with longer rest intervals.

Higher blood lactate levels with longer rest may indicate increased metabolic stress during training.

Exercise selection and rest interval length influence the rating of discomfort, with leg extensions producing less discomfort than back squats.

Selecting exercises with lower perceived discomfort may enhance training adherence.

3-methylhistidine and proline betaine concentrations increased consistently when participants were assigned a Prudent diet (q < 0.05) in both plasma and urine samples.

Practitioners can use these metabolites as biomarkers to monitor adherence to a Prudent diet.

Creatinine-normalized urinary imidazole propionate, hydroxypipecolic acid, dihydroxybenzoic acid, and enterolactone glucuronide increased with a Prudent diet (p < 0.05).

These metabolites can serve as indicators for dietary adherence to a Prudent diet.

Management strategies for weight regain include lifestyle interventions, pharmacotherapy, and revisional surgery.

A multidisciplinary approach incorporating these strategies is essential for effective long-term weight management.

High-intensity medical management leads to meaningful, though sometimes less substantial, weight loss and health improvements.

Practitioners should implement high-intensity medical management for patients preferring nonsurgical options.

The choice between metabolic surgery and high-intensity medical management should consider individual patient needs, health status, target weight loss, and personal preferences.

Practitioners should tailor treatment options based on individual patient circumstances.

Several anti-obesity drugs show significant reduction of fat mass, particularly visceral fat.

Practitioners can consider these drugs for effective fat loss, especially visceral fat.

GLP-1 receptor agonists suppress appetite and food reward to elicit rapid weight loss.

Practitioners can consider GLP-1 receptor agonists as effective options for weight loss.

Die Variation der mechano-biologischen Deskriptoren kann langfristig effektive Reize gestalten.

Incorporate varied training parameters to enhance long-term muscle growth.

Weight loss induced by a low-calorie diet resulted in an increase in serum 25-hydroxyvitamin D (25(OH)D) in both women and men by 12 nmol/L and 13 nmol/L respectively.

Weight loss through a low-calorie diet can improve vitamin D levels in individuals with obesity.

Further weight loss during the intervention had an additional beneficial impact on serum 25(OH)D in women.

Encouraging further weight loss in women may enhance vitamin D status.

Initial low serum 25(OH)D was associated with successful weight loss maintenance in women but not men.

Monitoring vitamin D levels may be important for weight loss maintenance strategies in women.

Tirzepatide is associated with a reduction in systolic arterial pressure by 4 to 6 mmHg and total cholesterol by 4–6% compared to baseline.

TZP may provide cardiovascular benefits in addition to glycemic control.

A significant proportion of patients with diabetes and hypertension experienced remission after ESG.

ESG may help improve metabolic health in overweight patients with these conditions.

The quality of life after ESG was rated as good or better by 82% of patients.

Practitioners can expect significant improvements in patient quality of life following ESG.

GLP-1 receptor agonists have better side-effect profiles than other weight management treatments.

Healthcare providers may prefer GLP-1 receptor agonists for patients due to their favorable side-effect profiles.

An oral formulation of semaglutide (7 or 14 mg once daily) has been approved by the FDA for the treatment of type 2 diabetes.

Practitioners can consider the oral formulation of semaglutide as an option for managing type 2 diabetes.

Myofibrillar protein synthesis rates did not differ between omnivorous and vegan dietary patterns.

Both omnivorous and vegan diets can support similar rates of muscle protein synthesis during resistance training.

These therapies may reduce the risk for HF hospitalizations.

Incorporating these therapies may help reduce hospital admissions for heart failure in this patient population.

Finerenone has been associated with reduced cardiovascular mortality and total worsening HF events across all BMI levels, with greater benefits observed in patients with higher BMIs.

Finerenone may be a beneficial treatment option for reducing cardiovascular risks in patients with varying BMI levels.

Oral semaglutide may provide greater attractiveness and better treatment adherence compared to subcutaneous semaglutide.

Oral semaglutide may be a preferable option for patients who prioritize ease of use.

Obesity and insulin resistance are associated with compromised muscle proteostasis.

Understanding the impact of obesity on muscle health can guide interventions.