Browse the evidence

The incidence of type 2 diabetes among non-operated patients with obesity was 11.7% during the follow-up period.

Non-operated obese patients have a high incidence of type 2 diabetes, highlighting the need for effective interventions.

The incidence of type 2 diabetes among gastric bypass patients was comparable to that of the general population.

Gastric bypass surgery can reduce diabetes risk to levels similar to those in the general population, indicating its effectiveness.

DXA-derived lean mass, BIA-derived skeletal muscle mass, and BodPod-derived fat-free mass overestimate D3-Cr-derived skeletal muscle mass.

Practitioners should be cautious of overestimations when using these common body composition assessment methods.

DXA, BIA, and ultrasound-derived appendicular lean mass uniformly underestimate D3-Cr-derived skeletal muscle mass by approximately 2.50 kg.

Practitioners should consider the potential underestimation when using these methods for assessing appendicular lean mass.

Food-related information is distributed across functionally distinct brain networks which act as opponent processes involved in guiding food-related behavior.

Understanding the distinct brain networks involved in food-related behavior can inform strategies for dietary interventions.

The inferred healthfulness or artificiality of foods is the greatest factor underlying similarity judgments, most strongly represented within the Prefrontal network.

Recognizing the impact of perceived healthfulness on food choices can aid in dietary planning.

The response to food images in the Prefrontal network is modulated strongly by judgments of the self-control required to resist eating those foods.

Understanding how self-control influences neural responses can help in developing strategies for better dietary choices.

PA may not be a critical factor influencing weight maintenance in PWD.

Weight maintenance strategies for PWD may need to consider factors beyond just physical activity.

There are trivial hypertrophic effects between proximal, mid-belly, and distal muscle sites.

Trivial differences in hypertrophy suggest that exercise selection may not need to prioritize specific muscle lengths.

The 'Competition Model of Metabolism' explains stability of physiological states despite metabolic perturbations.

Recognizing the mechanisms behind stability can inform interventions for weight management.

There is a strong imperative to assess the health effects of sugar-sweetened beverages as the burden of noncommunicable diseases increases.

Increased research on sugar-sweetened beverages is necessary to inform public health policies.

GLP-1 receptor agonists may modify aortic disorders through anti-inflammatory, antioxidant, and antiatherogenic properties.

GLP-1 RAs could be considered for patients with aortic disorders due to their beneficial properties.

Habitual sleep duration did not alter overfeeding-mediated body weight gain, fat gain, and fat distribution.

Sleep duration may not influence weight or fat gain during overfeeding.

Metabolic drugs such as GLP-1-based therapies and SGLT2 inhibitors have benefits that extend beyond metabolic improvements into changes in chronic inflammation.

Practitioners should consider the anti-inflammatory potential of metabolic drugs in clinical settings.

Physical frailty and sarcopenia are associated with morbidity and 2-fold mortality in patients with advanced chronic liver disease awaiting liver transplantation.

Healthcare providers should assess frailty and sarcopenia in liver transplant candidates to improve outcomes.

Early identification of physical frailty in the liver transplantation clinical pathway is essential for targeted interventions.

Clinicians should implement screening tools for frailty in liver transplant candidates to tailor interventions.

Transient reductions in fasting glucose were observed in participants with T2D, but these were not sustained and not significantly different from placebo at day 29.

While LY3537021 may reduce fasting glucose, the effects may not be long-lasting.

The evidence supporting GLP-1RAs for treating PsO and PsA remains limited.

Further clinical research is needed to establish the efficacy and safety of GLP-1RAs for PsO and PsA.

Environmental cues such as chronic cold exposure, exercise, and caloric restriction potentiate adipocyte browning.

Incorporating cold exposure, exercise, and caloric restriction may enhance browning and its benefits.

Loss of muscle-related indices exceeded prespecified benchmarks in two thirds of incretin-based interventions.

Clinicians should monitor muscle mass when prescribing incretin therapies for weight loss.

High-dose canagliflozin (300 mg/day) is significantly associated with reduced sepsis risk versus control.

Practitioners may consider high-dose canagliflozin as a safer option regarding sepsis risk.

Treatment duration had minimal influence on primary outcomes.

Practitioners may not need to adjust treatment duration based on infection risk concerns.

All active treatments, including Dapagliflozin 10 mg, Survodutide, Tirzepatide, and higher-dose Semaglutide, improved fibrosis versus placebo.

Practitioners can consider these anti-diabetic agents as effective options for improving liver fibrosis in patients with MASH.

Dose-dependent effects were more prominent for MASH resolution than fibrosis improvement.

Practitioners should consider the dosage of anti-diabetic agents when aiming for MASH resolution.