Browse the evidence

Postexercise hormonal spikes may enhance intracellular signaling to favor muscle protein synthesis.

Practitioners should consider the timing of workouts to maximize hormonal responses that support muscle growth.

Acute postexercise hormonal secretions may be more critical to hypertrophic adaptations than chronic changes in resting hormonal concentrations.

Emphasizing acute hormonal responses in training programs may enhance muscle growth outcomes.

The DAROC clinical practice guidelines for diabetes care- 2018 include recommendations for diagnostic criteria and treatment goals for various populations.

Practitioners should refer to the DAROC guidelines for comprehensive diabetes care recommendations.

Higher training frequency (2 days per week) may provide a slight benefit in some outcome measurements.

Consider incorporating higher training frequency for potentially better outcomes.

Both training frequencies (1 day/week and 2 days/week) significantly enhance neuromuscular adaptations.

Both training frequencies are effective for improving neuromuscular performance.

More repetitions performed in a set are associated with greater inaccuracy in RIR predictions.

Practitioners should consider the number of repetitions when assessing RIR to improve accuracy.

Lean mass remained stable in some cases, but notable reductions were observed in others, ranging from almost 0% to 40% of total weight reduction.

Clinicians should monitor lean mass changes in patients using semaglutide, as results can vary significantly.

Exercise in the supplemented condition significantly elevated plasma estradiol by approximately 83% for 90 minutes.

Resistance exercise combined with androstenedione supplementation significantly increases estradiol levels.

Reduced physical activity in nonagenarians is associated with less physical functionality.

Encouraging physical activity in older adults may improve their functional capabilities.

All trial arms had significant reductions in weight and hemoglobin A1c levels from baseline, but no significant differences were found between intervention arms and the control arm.

While all interventions led to weight and A1c reductions, the lack of differences suggests that any intervention may be beneficial.

Ingestion of long-chain triglyceride (LCT) solutions or infusion of intralipid before exercise leads to significant reductions in whole-body carbohydrate oxidation and decreased muscle glycogen utilization during moderate and intense dynamic exercise lasting 15-60 min.

Incorporating LCT solutions or intralipid infusions may help reduce carbohydrate usage during exercise.

Manipulation of aminoacidemia before resistance exercise via different patterns of intake of protein altered plasma AA profiles and postexercise intracellular signaling.

Practitioners should consider the timing and pattern of protein intake before resistance exercise to optimize amino acid profiles.

One-hour postexercise, phosphorylation of p70 S6K(thr389) and rpS6(ser235/6) was increased above baseline with BOLUS and PULSE, but not PLAC.

Increased phosphorylation indicates enhanced signaling for muscle protein synthesis after specific protein intake.

There was no difference in the enhancement of the muscle protein synthetic response after exercise between BOLUS and PULSE.

Both rapid and slow protein intakes can effectively promote muscle protein synthesis post-exercise.

Endoscopic sleeve gastroplasty (ESG) is more cost-effective than semaglutide over a 5-year time horizon, with an incremental cost-effectiveness ratio (ICER) of -$595,532/QALY.

Practitioners may consider ESG as a more cost-effective option for treating class II obesity compared to semaglutide.

AM833 is a novel nonselective agonist of calcitonin family receptors that has demonstrated efficacy for the treatment of obesity in phase 2 clinical trials.

AM833 may be a promising treatment option for obesity management.

Targeting amylin receptors improves weight control and may act additively with other treatments.

Combining treatments targeting amylin receptors may enhance obesity management strategies.

The high-bar back-squat (HBBS) is characterized by greater knee flexion, lesser hip flexion, a more upright torso, and a deeper squat compared to the low-bar back-squat (LBBS).

Practitioners can use HBBS to emphasize knee flexion and quadriceps engagement.

The low-bar back-squat (LBBS) is characterized by greater hip flexion and a greater forward lean compared to the high-bar back-squat (HBBS).

Practitioners can use LBBS to target hip musculature and posterior chain development.

The high-bar back-squat (HBBS) is associated with greater quadriceps muscle activity, while the low-bar back-squat (LBBS) is associated with greater muscle activity of the erector spinae, adductors, and gluteal muscles.

Practitioners can choose squat variations based on desired muscle engagement.

In men, resistance exercise has a similar effect on 24-h energy expenditure (EE) as a comparable bout of aerobic exercise.

Both resistance and aerobic exercises can be used interchangeably for managing energy expenditure.

24-h carbohydrate oxidation was significantly elevated on exercise days compared with a nonexercise control day.

Exercise increases carbohydrate oxidation, which may be beneficial for energy management.

Remission was greater in younger participants and those with shorter diabetes duration, higher C-peptide levels, higher HOMA %B, and lower insulin usage at baseline.

Younger patients and those with better baseline metabolic health may achieve better outcomes post-surgery.

Controlling for weight lost, diabetes remission remained nearly 4-fold higher after RYGB compared with LAGB.

RYGB may offer superior long-term diabetes remission compared to LAGB, independent of weight loss.