26,927 findings
- Energy balanceStrong
SNAP participants had less improvement in AHA diet scores compared to income-eligible nonparticipants and higher-income individuals, with a change in mean score of 0.57 for SNAP participants versus 2.56 and 3.84 for the other groups.
SNAP participants may need targeted interventions to improve their diet quality.
Refutes - Energy balanceStrong
Disparities in diet quality persisted for most foods and nutrients among US adults, with worsening disparities for processed meats, added sugars, and nuts and seeds.
Efforts to address dietary disparities should focus on specific food groups that are worsening.
Refutes - Metabolic adaptationStrong
Bariatric surgery was associated with a lower incidence of cardiovascular mortality, with an adjusted hazard ratio of 0.35.
Bariatric surgery may lead to lower rates of death from cardiovascular causes in this population.
Supports 2021 - Metabolic adaptationStrong
Bariatric surgery was associated with a lower incidence of the secondary outcome of 3-component MACE, with an adjusted hazard ratio of 0.66.
Bariatric surgery may reduce the risk of combined cardiovascular events in this patient group.
Supports 2021 - HormonalStrong
Ozempic users increased from 569 in 2019 to 7667 in 2020, with a count of 22,891 in 2022.
Practitioners should be aware of the rapid increase in Ozempic usage, indicating its growing acceptance and demand.
Supports 2023 - Metabolic adaptationStrong
Intakes of saturated fatty acids (SFAs), trans-fatty acids, animal monounsaturated fatty acids (MUFAs), α-linolenic acid, and arachidonic acid were associated with higher mortality.
Reducing intake of these fats may lower mortality risk.
Supports 2019 - Energy balanceStrong
Global mean intake of processed meat was 17 g/day, with mean national intakes of at least one serving per day for processed meat in countries representing 6.9% of the global population.
Health professionals should consider the prevalence of processed meat consumption in their dietary recommendations.
Supports 2022 - Metabolic adaptationStrong
Resting ATP levels were lower after LIT with OCC compared to before training.
Low-intensity resistance training with vascular occlusion may lead to lower ATP levels in muscles, indicating increased energy demand.
Supports 2003 - HormonalStrong
Adverse events were more frequent with liraglutide, with 80% of participants experiencing gastrointestinal events compared to 57% with placebo.
Clinicians should monitor for gastrointestinal side effects when prescribing liraglutide.
Supports 2023 - HormonalStrong
Insulin infusions without amino acids resulted in a progressive decrement in leucine Ra (14 to 45%), NORd (16-41%), and OXRd (3-56%) compared with basal values.
Insulin alone can significantly reduce protein breakdown, but the presence of amino acids enhances this effect.
Supports 1989 - HormonalStrong
Hypoaminoacidemia associated with insulin treatment blunts the responsiveness of insulin's suppression of protein breakdown.
Maintaining amino acid levels is crucial for maximizing insulin's effects on protein metabolism.
Supports 1989 - Energy balanceStrong
Fat adaptation did not significantly improve performance in a 1-h time trial after prolonged cycling.
Athletes should consider that fat adaptation may not enhance performance in all scenarios.
Refutes 2001 - CellularStrong
Resmetirom achieved resolution of steatohepatitis without worsening of fibrosis in 26%-30% of participants compared to 10% for placebo.
Resmetirom may be an effective treatment option for patients with MASH and moderate to advanced liver fibrosis.
Supports 2024 - CellularStrong
Resmetirom improved fibrosis without worsening of steatohepatitis in 24%-26% of participants compared to 14% for placebo.
Resmetirom may help improve liver fibrosis in patients with MASH without worsening their condition.
Supports 2024 - Energy balanceStrong
The food industry influences government nutrition policies and marketing practices.
Awareness of industry influence can guide healthier food choices.
Supports 2019 - Energy balanceStrong
The food industry prioritizes economic interests over health in its marketing strategies.
Recognizing the economic motivations can help consumers make informed choices.
Supports 2019 - Energy balanceStrong
In general populations, fish consumption of 350 g/week or more is not associated with risk of major CVD or total mortality.
For the general population, increasing fish intake beyond 350 g/week may not provide additional cardiovascular benefits.
Refutes 2021 - MolecularStrong
Neither glycogen depletion nor phosphorylation of relevant signalling proteins showed any difference between conditions of load and repetition duration.
Resistance training outcomes are not influenced by glycogen depletion or signalling protein changes based on load or repetition duration.
Supports 2019 - CellularStrong
BMI is negatively correlated with the expression levels of the long and short forms of UCP-3 (long: r = -0.53, P = 0.025; short: r = -0.46, P = 0.047).
Understanding the relationship between BMI and UCP-3 expression may help in developing strategies for managing energy expenditure.
Supports 1999 - CellularStrong
Metabolic rate during sleep, adjusted for fat-free mass and fat mass, is positively correlated with the long form of UCP-3 (r = 0.69, P = 0.006).
This finding suggests that UCP-3 may play a role in regulating metabolic rate during sleep, which could inform sleep and recovery strategies.
Supports 1999 - Energy balanceStrong
UCP-3 may be a determinant of energy expenditure and metabolic efficiency in Pima Indians.
Recognizing the role of UCP-3 in energy expenditure could lead to targeted interventions for metabolic health.
Supports 1999 - Energy balanceStrong
The quality of evidence supporting the recommendations on sugar intake is low to very low.
Practitioners should be cautious in applying these guidelines due to low evidence quality.
Refutes 2016 - Metabolic adaptationStrong
Corpulent phenotypes with subcutaneous fat accumulation display low cardiovascular mortality.
Practitioners should consider the protective effects of subcutaneous fat against cardiovascular mortality.
Supports 2015 - NeuralStrong
Non-habituators experience neuroenergetic alterations that promote visceral fat accumulation and cardiovascular events.
Understanding the differences in stress responses can help tailor interventions for cardiovascular health.
Supports 2015