Browse the evidence

The ability of insulin to suppress lipolysis is positively correlated with insulin sensitivity, ATpO2, vascular endothelial growth factor mRNA, and capillary density.

Improving insulin sensitivity and oxygenation in adipose tissue may enhance insulin's ability to suppress lipolysis.

Low capillary density and ATpO2 in adipose tissue are potentially upstream causes of adipose tissue dysfunction.

Addressing capillary density and oxygenation in adipose tissue may be important for improving metabolic health.

Total carbohydrate oxidation during steady-state exercise is similar regardless of the glycemic index of the preexercise meal.

This indicates that the type of carbohydrate consumed before exercise may not significantly impact energy utilization during prolonged cycling.

There is no difference in performance time for a subsequent ride after consuming different preexercise meals.

This suggests that athletes may not need to focus on the glycemic index of preexercise meals for performance outcomes.

Psychotropic drug-related weight gain (PDWG) is highly associated with non-initiation, discontinuation, and dissatisfaction with psychiatric drugs.

Practitioners should be aware of the impact of PDWG on patient adherence to psychiatric medications.

No difference was found between RTF and RTNF on maximal strength in overall analysis (SMD: -0.08; p = 0.642).

Both training methods may be equally effective for improving maximal strength.

The PCS-12 showed a greater decrease in HRQL associated with physical function compared with mental function-related domains of the MCS-12.

Practitioners should focus on improving physical function in patients with these risk factors.

There is significant variation in metabolic rate in humans, independent of differences in body size, body composition, age, and gender.

Practitioners should consider individual metabolic rates when assessing health and nutrition.

Fasting oral temperatures varied more between individuals than can be attributed to methodological errors or intraindividual variation.

Individual variations in body temperature should be considered in health assessments.

Oral temperatures correlated with sleeping and 24-h metabolic rates adjusted for differences in body size, body composition, and age.

Understanding the correlation between body temperature and metabolic rate can aid in metabolic health assessments.

Calorie restriction/dieting was not associated with a consistent pattern of cognitive impairment.

Practitioners can consider that calorie restriction may not negatively impact cognitive function based on this trial's findings.

The dietary glycemic load did not influence chronic adaptations in glucose-insulin dynamics beyond what was associated with weight loss.

Focus on weight loss rather than dietary glycemic load for improving glucose-insulin dynamics.

Federal dietary advice has shifted from 'decrease consumption of meat' to 'have two or three (daily) servings' under pressure from meat producers.

Practitioners should consider how dietary guidelines may be influenced by industry interests.

No significant changes in quadriceps cross-sectional area were observed in the low-load not to failure group.

Avoid low-load training without reaching muscle failure if hypertrophy is the goal.

Lowering dietary fat has led to an underestimation of the potential role of dietary composition in promoting reductions in energy intake and weight loss.

Practitioners should consider the role of dietary composition beyond just fat reduction in weight loss strategies.

There were no statistical differences in EMG amplitude between full, front, and parallel squats in any of the tested muscles.

Trainers can choose any squat variation without concern for differences in muscle activation.

Higher genetically determined BMI is not associated with insulin secretion.

This suggests that BMI may not directly influence insulin secretion, which could inform treatment approaches.

Insulin resistance is associated with a breakdown in lipid dynamics.

Recognizing the role of lipid dynamics in insulin resistance can inform treatment strategies.

SMR in stage 3 sleep was significantly lower than in stage 2 and rapid eye movement sleep.

Recognizing the metabolic differences across sleep stages can inform sleep hygiene practices.

Sleep stages are associated with only small differences in energy metabolism.

While sleep stages affect metabolism, their impact is limited, suggesting other factors may be more significant.

Significant disproportionality for semaglutide remained in patients with coreported use of antidepressants and benzodiazepines.

Clinicians should consider the interaction of semaglutide with antidepressants and benzodiazepines when assessing risk.

Randomised controlled trials have not provided conclusive evidence that physical activity started during adulthood extends lifespan.

Caution should be exercised in claiming lifespan benefits from adult physical activity alone.

The health-related benefits of exercise have not yet translated into a proven causal relationship with longevity.

While exercise is beneficial, its direct impact on longevity remains unproven.

Using respiratory chambers for these studies should improve understanding of body weight regulation.

This suggests that improved measurement techniques can lead to better strategies for managing body weight.