Browse the evidence

Increased fatty acid availability does not systematically improve exercise capacity despite substantial muscle glycogen sparing (15-48% compared with control).

Increased fat availability may not enhance performance, even with reduced glycogen use.

The effects of increased fatty acid provision on rates of muscle glucose uptake during exercise are equivocal.

The impact of fat availability on glucose uptake during exercise remains unclear.

Fewer than half of adults with type 2 diabetes mellitus attain therapeutic goals for glycemic control.

Healthcare providers should be aware that many patients are not achieving glycemic control and may need alternative interventions.

Lifestyle interventions for type 2 diabetes are disappointing in the long term.

Practitioners may need to seek alternative strategies beyond lifestyle changes for effective diabetes management.

No significant effects of age were observed in changes in total energy expenditure (TEE), resting energy expenditure (REE), thermic effect of feeding (TEF), or body energy loss in response to underfeeding.

Practitioners can consider that age does not significantly affect energy expenditure during underfeeding in healthy men.

Older men do not appear to have any impairment of energy conservation during negative energy balance compared to young men.

Practitioners can conclude that older men maintain energy conservation during periods of underfeeding.

The normal pattern of energy conservation during undereating, combined with reduced energy dissipation during overeating, may promote body fat deposition in older men.

Practitioners should be aware that older men may be at risk for increased body fat due to energy balance patterns.

To achieve nondominance, the annual price of semaglutide would need to be reduced from $13,618 to $3,591.

This suggests that pricing strategies for semaglutide could significantly impact its adoption in clinical practice.

AM833 has a unique pharmacological profile across diverse measures of receptor binding, activation, and regulation.

Understanding AM833's unique profile can inform its therapeutic use.

64% of the adult population in the United States is either overweight or obese.

Healthcare providers should be aware of the high prevalence of obesity in their patient population.

Neither exercise produced an increase in 24-h fat oxidation above that observed on a nonexercise control day.

Exercise may not enhance fat oxidation beyond resting levels, suggesting a need for varied strategies for fat loss.

Liraglutide has some common adverse effects, although generally not serious ones.

Practitioners should be aware of potential side effects when prescribing liraglutide.

Obesity has tripled in the last 10 years, killing approximately 28 million people each year.

Health practitioners should be aware of the growing obesity epidemic and its significant mortality impact.

Cardiomyocyte lipid aggregation in obesity causes insulin resistance and cardiovascular hypertrophy, reducing overall heart function.

Interventions targeting lipid metabolism may improve heart function in obese patients.

The review emphasizes moving from a binary approach to a quantitative approach in trials regarding glycaemic exposure.

Researchers should consider adopting quantitative measures of glycaemic exposure in future trials to better assess cardiovascular outcomes.

There was no overall pooled effect on HbA1c in favor of restricting carbohydrate.

Carbohydrate restriction may not significantly improve glycaemic control in Type 2 diabetes.

Fasting ghrelin levels significantly increased from baseline in all three intervention groups.

Dietary interventions may increase ghrelin levels, which could influence hunger and metabolism.

Acute high-intensity interval exercise decreased Na+ -K+ -ATPase activity by 12.7% and increased alpha1, alpha2, and alpha3 mRNA expression by 1.4-, 2.8-, and 3.4-fold, respectively.

High-intensity interval exercise can significantly alter Na+ -K+ -ATPase activity and mRNA expression in trained athletes.

Post-training, the acute exercise-induced decline in Na+ -K+ -ATPase activity and increase in alpha1 and alpha3 mRNA persisted.

The effects of acute exercise on Na+ -K+ -ATPase activity and mRNA expression can last beyond the training period.

The implementation of MTMs could potentially lead to net cost savings of $13.6 billion annually from a health care perspective.

Expanding coverage for MTMs could be a financially beneficial policy for healthcare systems.

Choosing the optimal diet therapy for a patient with NAFLD is complicated due to the multifactorial nature of the disease.

Practitioners should recognize the complexity in selecting diet therapies for NAFLD patients.

The evidence for the benefits of power training on physical function and self-reported function was rated as low-certainty.

Practitioners should be aware of the limitations in the evidence when recommending power training.

Two weeks of reduced-volume sprint interval training (SIT) did not improve metabolic functioning in sedentary obese men.

Short-term exercise interventions may not be sufficient to induce metabolic changes in sedentary obese individuals.

Immobilization rapidly reduces ADP‐stimulated mitochondrial respiration by approximately 20% within 3 days.

Understanding the rapid decline in mitochondrial function can inform rehabilitation strategies post-immobilization.