Browse the evidence

Higher levels of circulating lignoceric acid are associated with a 16% lower risk of unhealthy aging events.

Practitioners may consider monitoring lignoceric acid levels as a potential marker for healthy aging.

The study highlights the need to explore determinants of circulating very-long-chain saturated fatty acids (VLSFAs) for promoting healthy aging.

Practitioners and researchers should consider investigating VLSFAs further to enhance strategies for healthy aging.

GLP-1RAs have gastrointestinal side effects, particularly nausea, which limits their tolerability.

Clinicians should monitor for gastrointestinal side effects when prescribing GLP-1RAs.

Within the diabetes support and education (DSE) group, cardiovascular disease outcomes did not differ.

DSE alone may not be sufficient to impact cardiovascular outcomes compared to intensive lifestyle interventions.

Baseline HbA1c levels were associated with reduced odds of type 2 diabetes remission after bariatric surgery (pooled difference in means = -1.05, 95% CI = -1.48 to -0.62, p < .001).

Practitioners should monitor HbA1c levels as they may indicate lower chances of remission post-surgery.

Fasting plasma glucose (FPG) levels were associated with reduced odds of type 2 diabetes remission after bariatric surgery (pooled standardized mean difference = -0.42, 95% CI: -0.64 to -0.20, p < .004).

Practitioners should consider FPG levels as a factor that may negatively impact remission rates post-surgery.

The safety profile of tirzepatide was broadly similar across BMI and age subgroups, but drug discontinuation due to adverse events was higher in participants aged ≥ 65 years.

While generally safe, practitioners should monitor older patients closely when prescribing tirzepatide.

Disparities in the use of SGLT-2 inhibitors and GLP-1 receptor agonists exist based on race, sex, and socioeconomic status.

Efforts should be made to address these disparities in prescribing practices.

The American and European guidelines have similar approaches to CVD prevention but also have some differences.

Clinicians should be aware of both similarities and differences in guidelines for tailored patient care.

Stable isotope tracers have significantly advanced the understanding of muscle protein turnover.

Utilizing stable isotope tracers can enhance research and understanding of muscle protein metabolism.

Systolic blood pressure was not statistically different between traditional resistance training (RT) and high velocity resistance training (HVRT) at the beginning and during 30 minutes after sessions.

Both training modalities may be equally effective in managing systolic blood pressure in this population.

There were no differences for psychophysiological variables between traditional resistance training (RT) and high velocity resistance training (HVRT).

Practitioners can expect similar psychophysiological outcomes from either training modality in this demographic.

Traditional recommendations for obesity treatment are largely ineffective.

Practitioners should be aware that traditional methods may not yield results.

There has been a revolution in understanding the molecular and neural control of appetite and body weight.

Understanding these mechanisms can inform treatment strategies for obesity.

C-reactive protein levels decreased after one year of GLP1-RA treatment.

Monitoring C-reactive protein levels may help assess the effectiveness of GLP1-RA in IBD.

23% of participants reported any adverse event while using GLP-1RAs, with 7% discontinuing treatment.

While GLP-1RAs are generally well-tolerated, practitioners should monitor for adverse events.

HMB demonstrated no significant effect on body mass (BM) in athletes.

Athletes should not expect HMB to significantly affect their body weight.

HMB has a small, nonsignificant effect on fat mass (FM) in athletes.

HMB may have a minimal effect on reducing fat mass, but it is not statistically significant.

Obesity and its associated conditions significantly impact healthcare systems, life expectancy, and quality of life.

Addressing obesity is crucial for improving healthcare outcomes and quality of life.

Ghrelin is an orexigenic hormone, while GLP-1, GIP, CCK, PYY, and OXM are anorexigenic hormones.

Understanding the roles of these hormones can help in developing targeted interventions for appetite regulation.

Higher BMI in monozygotic twins is associated with an increased risk of incident diabetes.

Practitioners should be aware that higher BMI in twins correlates with a higher risk of diabetes.

Increases in BMI over the past 30 years were not associated with later risk of myocardial infarction or death but were associated with the risk of incident diabetes.

Practitioners should note that long-term increases in BMI may not affect cardiovascular risk but do relate to diabetes risk.

Seven foods contributed 50% of total energy intake in the Mexican population aged 5 years and older.

Practitioners should focus on these key foods when addressing energy intake in dietary recommendations.

There is great heterogeneity in energy intake among different subgroups of the Mexican population.

Dietary interventions may need to be tailored to specific subgroups to be effective.