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Supplemental protein from whey and pea increased integrated myofibrillar protein synthesis (MPS) rates to 1.59 ± 0.11 %/d and 1.59 ± 0.14 %/d respectively, compared to the RDA of 1.46 ± 0.09 %/d for whey and 1.46 ± 0.10 %/d for pea.

Practitioners should consider whey and pea protein supplements for older males to enhance muscle protein synthesis.

Supplemental protein improved anabolic signaling and integrated MPS in older males.

Incorporating protein supplements into meals can enhance muscle health in older adults.

Tirzepatide has shown greater clinical efficacy in reducing HbA1c and body weight compared with placebo or selective GLP-1 RAs.

Tirzepatide may be a more effective option for managing HbA1c and body weight in patients compared to existing therapies.

Contrast training (CT) results in greater countermovement jump (CMJ) gains compared to resistance training (RT) with an effect size of 1.30.

Practitioners may consider incorporating contrast training to enhance vertical jump performance.

Contrast training (CT) shows higher countermovement jump (CMJ) performance compared to control groups with an effect size of 1.46.

Incorporating contrast training may lead to better jump performance compared to standard training.

Cardiovascular mortality was 30% higher in individuals with very low adherence to dietary guidelines compared to those with very high adherence.

Highlighting the importance of dietary adherence can help reduce cardiovascular mortality.

Non-cardiovascular mortality was 54% higher in individuals with very low adherence to dietary guidelines compared to those with very high adherence.

Emphasizing dietary adherence can also help reduce non-cardiovascular mortality.

Low-load resistance training with blood flow restriction (LL-BFR) leads to significant increases in cross-sectional area (CSA) of quadriceps muscles without the presence of muscle edema.

Practitioners can utilize LL-BFR for muscle growth without the concern of edema.

High-load resistance training (HL-RT) results in significant increases in CSA and is influenced by muscle edema.

Practitioners should consider HL-RT for muscle growth, noting the role of edema.

A single set resistance training program performed two days per week can improve cellular health indicators in older women.

Practitioners can consider recommending a two-day per week resistance training program for older women to enhance cellular health.

Resistance training performed three days per week also improves cellular health indicators in older women.

Practitioners can also recommend a three-day per week resistance training program for older women to enhance cellular health.

Both pyramid (PR) and constant (CT) resistance training systems significantly improve muscular strength and muscle mass in resistance-trained older women.

Both training methods can be used effectively to enhance strength and muscle mass in older women.

Semaglutide therapy resulted in a 62.9% resolution of MASH without worsening of fibrosis compared to 34.3% in placebo (p <0.001).

Clinicians can consider semaglutide as an effective treatment option for MASH with moderate-to-advanced fibrosis.

Lifestyle modification remains the cornerstone of MASLD/MASH management alongside semaglutide.

Practitioners should emphasize lifestyle changes in addition to pharmacotherapy for optimal management.

Significant within-group increases in 1-RM bench press were observed for MJ, MJ + SJ, and SJ + MJ but not for SJ.

Varying the order of exercises can enhance strength gains in bench press.

Significantly greater increases in PM CSA were observed for MJ, MJ + SJ, and SJ + MJ compared with SJ.

Incorporating multi-joint exercises can lead to greater muscle growth in the pectoralis major.

Significantly greater increases in elbow extension 1-RM were noted for SJ, MJ + SJ, and SJ + MJ but not for MJ.

Single-joint exercises can be effective for improving elbow extension strength.

Both varied and constant loading approaches can promote significant improvements in muscular adaptations in trained young men.

Trainers can use either varied or constant loading protocols to enhance muscle strength and endurance.

Both groups significantly increased markers of muscle strength, muscle thickness, and local muscular endurance.

Resistance training effectively enhances muscle strength and endurance in trained individuals.

Effect sizes favored VARIED over CONSTANT for several muscular adaptations.

Varied loading protocols may yield greater muscular adaptations compared to constant loading.

Intentionally reaching failure during resistance exercise sets is beneficial for stimulating hypertrophy.

Coaches should incorporate failure training to enhance muscle growth.

The greatest effectiveness of failure training occurs when practiced consistently over 6-week cycles, interspersed with non-failure training.

Implement structured training cycles for optimal results in hypertrophy.

High-Intensity Interval Training (HIIT) improves cardiorespiratory fitness and health.

HIIT can be effectively incorporated into fitness training programs to enhance fitness levels.

HIIT is effective for reducing body fat levels.

Incorporating HIIT into training can aid in fat loss efforts.