Browse the evidence

Weight loss through a healthy lifestyle can reduce morbidity and mortality associated with diabesity.

Encouraging weight loss through lifestyle changes is essential in managing diabesity.

Face-to-face interventions demonstrated a significant 46% risk reduction in T2DM incidence and a 46% increase in the reversion to normoglycemia compared with the control group.

Practitioners should prioritize face-to-face interventions for effective T2DM prevention and normoglycemia reversion.

Digital health interventions were associated with a 12% risk reduction in T2DM incidence compared with the control group.

Digital health interventions may offer some benefit, but practitioners should be cautious due to the lack of significant evidence.

Blended interventions combining digital and face-to-face approaches suggested a 37% risk reduction in T2DM incidence and an 87% increase in the reversion to normoglycemia.

Blended interventions may be highly effective and should be considered in T2DM prevention strategies.

The HoDiRECT Nepal project demonstrated the feasibility of a low-calorie traditional Nepali diet for diabetes remission.

Practitioners can consider low-calorie traditional diets as a viable option for diabetes remission.

Participants' motivation to enroll in the program was driven by their desire to stop taking diabetes medications, achieve better diabetes control, and lose weight.

Understanding participant motivations can help tailor interventions for diabetes management.

Adherence to a weight-loss regimen can be enhanced if the diet is simple to prepare and if there is greater education for patients and their communities about diabetes.

Simplifying diet preparation and enhancing education can improve adherence to diabetes management programs.

Participants who completed the nutritional counselling intervention demonstrated significant improvements from baseline in all anthropometric measures, including weight, BMI, and waist circumference.

Nutritional counselling can effectively improve key anthropometric measures in prediabetic patients.

Weight loss was achieved independently of genetic risk scores (GRS).

Practitioners can consider that GRS may not be a reliable predictor of weight loss outcomes in similar interventions.

DEA-derived efficiency scores strongly predicted the change in BMI percentage.

Practitioners may use DEA-derived efficiency scores to better predict weight loss outcomes.

Integrated metrics incorporating phenotypic data show potential for personalizing weight management strategies.

Practitioners should consider using integrated metrics for more effective weight management strategies.

Integrating continuous glucose monitoring (CGM) with a digital weight management program produced a 0.46% greater reduction in HbA1c% compared to usual care.

Healthcare providers can consider integrating CGM with weight management programs for better glycemic control.

The intervention group had a 3.2% greater reduction in percent body weight compared to the usual care group.

Weight management programs should incorporate continuous glucose monitoring for enhanced effectiveness.

The intervention group experienced significantly greater improvements in diabetes treatment satisfaction and regimen-related diabetes stress compared to usual care.

Improving treatment satisfaction can enhance adherence to diabetes management strategies.

The Gothenburg physical activity on prescription (PAP) intervention produced sustained increases in physical activity of approximately 730 MET-min/week with about 50% adherence at 5 years.

Practitioners can implement PAP to effectively increase physical activity in patients with metabolic risk.

Significant improvements were observed in cardiometabolic risk markers, mental health, and exercise capacity among participants.

Enhancing physical activity can lead to improved health outcomes in at-risk populations.

Six weeks of physiotherapist-led structured physical exercise program (SPEP) improved glycemic control in adults with type 2 diabetes mellitus (T2DM).

Incorporating structured exercise programs can enhance glycemic control in diabetic patients.

The experimental group showed greater improvements in physical fitness as measured by the 6-minute walk test (6MWT).

Structured exercise can significantly enhance physical fitness in diabetic individuals.

Weekly subcutaneous Semaglutide 2.4 mg results in a -13.7% body weight reduction.

Practitioners may consider Semaglutide as an effective weight loss therapy for women with preeclampsia.

Body weight decreased by 9.8% in adults with obesity and type 2 diabetes and by 5.3% in adults with overweight/obesity without diabetes.

Both groups experienced significant weight loss, which is a common goal in obesity management.

The digital health application Oviva Direkt yielded cost savings of 3,511.85 € and a QALY gain of 0.0683 (approximately 3.6 weeks in perfect health) compared to care as usual.

Digital health applications can be a cost-effective option for obesity treatment.

Direct medical costs were reduced by nearly 520 € with the use of the digital health application.

Implementing digital health applications can lead to significant reductions in medical costs.

The prevalence of type-2 diabetes (T2D) was 1.6 percentage points lower in patients using the digital health application.

Digital health applications may contribute to lower diabetes prevalence and improved health outcomes.

Carbohydrate restriction leads to appetite reduction, weight loss, and improvements in glycemic and insulin control.

Practitioners may consider carbohydrate restriction as a strategy for managing obesity and T2DM.