Browse the evidence

In older adults (≥65 years), distributing daily protein intake evenly across meals does not significantly increase muscle protein synthesis (MPS) or strength gains compared to an uneven distribution, despite theoretical models suggesting a per-meal threshold of 0.4 g/kg optimizes MPS.

For older adults engaging in resistance training, ensuring you eat enough protein throughout the day is important, but you likely do not need to stress about hitting a specific high amount (like 0.4g per kg of body weight) at every single meal. The study showed that spreading protein evenly did not provide extra muscle-building benefits over an uneven distribution when combined with exercise. Focus on getting adequate total protein and lifting weights consistently.

Overall low-carbohydrate diet (LCD) scores were not associated with mortality in the whole population of the study.

Practitioners should note that overall LCD scores do not predict mortality risk in this population.

Altering the proportion of energy from fat in daily snacks has no effect on weight.

Practitioners may not need to focus on fat content in snacks for weight management.

Altitude-associated hypoxia may trigger significant reductions in energy intake.

Consideration of energy intake is important when evaluating the effects of hypoxia on metabolic health.

There are predisposing risk factors for type 2 diabetes that can be reviewed.

Understanding risk factors can help in tailoring prevention strategies for individuals.

Exercise may improve glycemic control through key cellular and molecular adaptive processes.

Practitioners should consider the types of exercise that promote these adaptive processes for better glycemic control.

Further studies, including clinical trials, are needed to investigate the effects of a low carbohydrate diet on type 2 diabetes.

There is a need for more rigorous research to clarify the impact of low carbohydrate diets on diabetes management.

Higher dietary cholesterol intake (≥300 mg/day) was associated with a higher risk of total mortality (HR 1.19 [95% CI 1.04, 1.37]).

Limiting dietary cholesterol intake may reduce mortality risk in Korean populations.

The program should be tested for transferability to work health promotions outside the military.

Consideration for adapting military health programs for civilian workplace settings.

Semaglutide likely results in little to no difference in quality of life with a mean difference of 2.12 (95% CI 0.95 to 3.28) in SF-36 physical functioning score at medium-term follow-up.

While semaglutide aids in weight loss, its impact on quality of life may be minimal.

By 2025, GLP-1RAs are anticipated to receive FDA approval for new indications including chronic kidney disease and heart failure.

Healthcare providers should stay informed about upcoming indications for GLP-1RAs to optimize treatment options.

White meat, red meat, dairy, starch, fruits, vegetables, and legumes intake were not associated with incident IBD.

Practitioners can consider that traditional food groups may not contribute to IBD risk as ultra-processed foods do.

Baseline disease severity, depressive symptoms, insulin resistance, and preperitoneal fat were negatively associated with PASI improvement.

Understanding these associations can help tailor treatment strategies for better outcomes.

Current evidence on the cardiovascular safety of tirzepatide is limited but suggestive.

Caution is advised when considering tirzepatide for patients with cardiovascular issues due to limited evidence.

Tirzepatide may have potential therapeutic effects on metabolic dysfunction-associated steatohepatitis (MASH).

Tirzepatide could be explored as a treatment option for patients with MASH, pending further research.

In China, there was no significant association between white rice intake and diabetes risk (HR: 1.05; 95% CI: 0.78-1.41, p for trend = 0.38).

Dietary recommendations regarding white rice may not apply uniformly across different populations, such as in China.

A variety of clinical tools exist to assess nutritional status, sarcopenia, and physical frailty in liver transplant recipients.

Practitioners should utilize available assessment tools to evaluate frailty and nutritional status in liver transplant patients.

Gastrointestinal adverse effects are the most common safety concern associated with incretin analogs.

Clinicians should monitor for gastrointestinal side effects when prescribing incretin analogs.

Weight loss may increase the risk for atherosclerosis among participants who were obese at baseline.

Weight loss in obese individuals should be approached with caution regarding atherosclerosis risk.

16.4% of participants were at high-risk for atherosclerosis as measured by cIMT.

A significant portion of the population studied is at high risk for atherosclerosis, indicating a need for preventive measures.

Aspiration therapy meets safety and effectiveness thresholds for incorporation into routine practice, but overall acceptance has been lower than other FDA-approved EBMTs.

Practitioners should be aware of the safety of aspiration therapy, but also its limited acceptance among patients.

The use of safe and effective weight-loss medications may influence referral patterns for MBS in the future.

Practitioners should consider the evolving landscape of obesity treatment when referring patients for MBS.

Tirzepatide is under evaluation for treatment of non-alcoholic steatohepatitis, heart failure, and obstructive sleep apnea.

Practitioners should consider Tirzepatide's potential for treating these additional conditions in future practice.

There is an increasing prevalence of obesity in individuals with type 1 diabetes.

Healthcare providers should be aware of the rising obesity rates in type 1 diabetes patients for better management.