Browse the evidence

Weight loss induced by a low-calorie diet resulted in an increase in serum 25-hydroxyvitamin D (25(OH)D) in both women and men by 12 nmol/L and 13 nmol/L respectively.

Weight loss through a low-calorie diet can improve vitamin D levels in individuals with obesity.

Further weight loss during the intervention had an additional beneficial impact on serum 25(OH)D in women.

Encouraging further weight loss in women may enhance vitamin D status.

Initial low serum 25(OH)D was associated with successful weight loss maintenance in women but not men.

Monitoring vitamin D levels may be important for weight loss maintenance strategies in women.

Tirzepatide is associated with a reduction in systolic arterial pressure by 4 to 6 mmHg and total cholesterol by 4–6% compared to baseline.

TZP may provide cardiovascular benefits in addition to glycemic control.

A significant proportion of patients with diabetes and hypertension experienced remission after ESG.

ESG may help improve metabolic health in overweight patients with these conditions.

The quality of life after ESG was rated as good or better by 82% of patients.

Practitioners can expect significant improvements in patient quality of life following ESG.

GLP-1 receptor agonists have better side-effect profiles than other weight management treatments.

Healthcare providers may prefer GLP-1 receptor agonists for patients due to their favorable side-effect profiles.

An oral formulation of semaglutide (7 or 14 mg once daily) has been approved by the FDA for the treatment of type 2 diabetes.

Practitioners can consider the oral formulation of semaglutide as an option for managing type 2 diabetes.

Myofibrillar protein synthesis rates did not differ between omnivorous and vegan dietary patterns.

Both omnivorous and vegan diets can support similar rates of muscle protein synthesis during resistance training.

These therapies may reduce the risk for HF hospitalizations.

Incorporating these therapies may help reduce hospital admissions for heart failure in this patient population.

Finerenone has been associated with reduced cardiovascular mortality and total worsening HF events across all BMI levels, with greater benefits observed in patients with higher BMIs.

Finerenone may be a beneficial treatment option for reducing cardiovascular risks in patients with varying BMI levels.

Oral semaglutide may provide greater attractiveness and better treatment adherence compared to subcutaneous semaglutide.

Oral semaglutide may be a preferable option for patients who prioritize ease of use.

Obesity and insulin resistance are associated with compromised muscle proteostasis.

Understanding the impact of obesity on muscle health can guide interventions.

HIIT tends to benefit proteostasis by increasing muscle protein turnover rates.

HIIT may be a beneficial strategy for enhancing muscle health in obese individuals.

The vasti, soleus, and gluteus maximus generated the largest upward accelerations of the center of mass during the barbell back squat.

Strength coaches should focus on training the vasti, soleus, and gluteus maximus for improved squat performance.

Muscle function during squatting is task and posture specific, depending on joint position and environmental interaction.

Practitioners should consider joint positions and task-specific demands when designing squat training programs.

Dual and triple agonists show effectiveness on validated surrogate NAFLD biomarkers.

There is potential for dual and triple agonists to be effective in treating NAFLD, warranting further investigation.

48% of individuals exhibited exercise-related energy compensation (ExEC) with a mean of −308 ± 158 kcals/day.

Practitioners should note that a significant portion of individuals may not fully compensate for exercise energy expenditure.

Exercise-related energy compensation occurs independent of metabolic adaptation.

This indicates that practitioners should not expect metabolic adaptations to accompany energy compensation from exercise.

GIP receptor agonism and antagonism both lead to weight reduction.

Both GIP receptor agonists and antagonists could be explored for obesity treatment strategies.

Lifestyle recommendations for nutritional care and physical activity in diabetes management are poorly implemented.

Practitioners should enhance the implementation of lifestyle interventions in diabetes care.

The macrovascular benefits of GLP-1 receptor agonists should be prioritized over potential microvascular progression of DR.

Healthcare providers should weigh the cardiovascular benefits of GLP-1 receptor agonists against the risks of worsening DR.

GLP-1RA is underutilized due to cardiologists' unfamiliarity and hesitation.

Addressing these barriers could improve GLP-1RA utilization in clinical practice.

Endoscopic sleeve gastroplasty is a novel technique of endoscopic bariatric therapies that has shown safety, efficacy, and cost-effectiveness.

Practitioners can consider endoscopic sleeve gastroplasty as a viable option for patients who are not candidates for traditional bariatric surgery.