Research
Cellular
The relative effectiveness of intensive lifestyle intervention (ILI) on cardiovascular disease (CVD) incidence is inversely related to baseline frailty index (FI) in a graded fashion.
Practitioners should consider the frailty status of patients when recommending lifestyle interventions for CVD risk reduction.
StrongSupportsmedium confidence
The relative effectiveness of ILI on CVD incidence was inversely related to baseline FI in a graded fashion (p = .01).
Why this rating
The study is based on a large randomized controlled trial with significant follow-up.
Source
Does the Impact of Intensive Lifestyle Intervention on Cardiovascular Disease Risk Vary According to Frailty as Measured via Deficit Accumulation?
Felicia Simpson et al. · The Journals of Gerontology Series A · 2020
DOI 10.1093/gerona/glaa153
cohort · n=4859Cited 16×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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