Research
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Individuals in the first tertile of frailty index experienced a relative benefit from ILI with a hazard ratio of 0.73.
Less frail individuals may benefit more from intensive lifestyle interventions for CVD risk reduction.
StrongSupportsmedium confidence
Relative benefit (hazard ratio = 0.73 [95% CI 0.55,0.98]) for individuals in the first FI tertile.
Why this rating
The study is based on a large randomized controlled trial with significant follow-up.
Source
Does the Impact of Intensive Lifestyle Intervention on Cardiovascular Disease Risk Vary According to Frailty as Measured via Deficit Accumulation?
Felicia Simpson et al. · The Journals of Gerontology Series A · 2020
DOI 10.1093/gerona/glaa153
cohort · n=4859Cited 16×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The relative effectiveness of intensive lifestyle intervention (ILI) on cardiovascular disease (CVD) incidence is inversely related to baseline frailty index (FI) in a graded fashion.Strong
- There was no benefit from ILI for individuals in the third tertile of frailty index, with a hazard ratio of 1.15.Strong
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