Research
Cellular
There was no benefit from ILI for individuals in the third tertile of frailty index, with a hazard ratio of 1.15.
Practitioners should be cautious in recommending intensive lifestyle interventions for more frail individuals.
StrongSupportsmedium confidence
No benefit (hazard ratio = 1.15 [0.94,1.42]) among those in the third FI tertile.
Why this rating
The study is based on a large randomized controlled trial with significant follow-up.
Source
Does the Impact of Intensive Lifestyle Intervention on Cardiovascular Disease Risk Vary According to Frailty as Measured via Deficit Accumulation?
Felicia Simpson et al. · The Journals of Gerontology Series A · 2020
DOI 10.1093/gerona/glaa153
cohort · n=4859Cited 16×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The relative effectiveness of intensive lifestyle intervention (ILI) on cardiovascular disease (CVD) incidence is inversely related to baseline frailty index (FI) in a graded fashion.Strong
- Individuals in the first tertile of frailty index experienced a relative benefit from ILI with a hazard ratio of 0.73.Strong
Related findings · Cellular
- Athletes aiming to reduce fat mass and preserve FFM should consume protein intakes in the range of ∼1.8-2.7 g kg(-1) d(-1).Strong
- A minimum daily protein intake of ≥1.6 g/kg is necessary to observe significant improvements in muscle mass from whey protein supplementation.Strong
- Most athletes ideally need 1.2 to 2.0 grams/kg of body weight/day of protein, preferably split across 3-4 meals.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →