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Changes in VAT are primarily determined by changes in total fat mass and the initial VAT to FM ratio.

Understanding the relationship between total fat mass and visceral fat can guide weight loss strategies.

Resistance training with a 7-9 RPE may elicit marginally greater acute responses of CK and LDH than 4-6 RPE over time.

Practitioners may consider incorporating higher RPE levels to enhance muscle damage responses.

The 7-9 RPE group demonstrated a greater acute response of CK and LDH compared to the 4-6 RPE group.

Higher RPE training may be more effective for inducing muscle damage.

The model coefficient for the interaction of week by time point demonstrates evidence of the repeated bout effect for CK but not LDH.

Understanding the repeated bout effect can help in planning training cycles.

Resting muscle glycogen content was approximately 300% higher in high glycogen (HG) than low glycogen (LG) conditions.

Higher muscle glycogen levels significantly enhance carbohydrate availability for exercise.

The training specific adaptive response is influenced by the overload stimulus and individual muscle fibre type.

Understanding individual muscle fibre types can help tailor training programs for better results.

Muscle glycogen concentration affects anabolic signaling following resistance exercise, with divergent glycogen levels observed between low and normal glycogen legs.

Practitioners should consider the impact of muscle glycogen levels on anabolic signaling when designing resistance training programs.

BOLUS ingestion increased phosphorylation of p70S6K Thr389 above rest only at 1 h (∼20 fold) and 7 h post-exercise (∼12 fold; both p<0.05).

Consuming a larger bolus of protein post-exercise may enhance anabolic signaling more effectively than smaller, more frequent doses.

Muscle glycogen utilization was higher on DAY 3 (600 ± 86 mmol·kg−1 dw) compared to both DAY 1 (340 ± 84 mmol·kg−1 dw) and DAY 5 (350 ± 51 mmol·kg−1 dw, P <0.001).

Athletes may experience higher glycogen utilization during exercise on the third day of a high CHO diet, which could impact performance.

Participants expressed a strong preference for various types of weight loss help, with 100% wanting to read educational articles.

Practitioners should prioritize educational materials in their weight loss programs for this group.

sACE2 decreased significantly on average at 6-months in the diet intervention.

Weight loss interventions may lead to significant decreases in sACE2 levels.

Decrease in sACE2 during a weight loss diet intervention was associated with improvements in fat mass and markers of chronic inflammation.

Weight loss may lead to beneficial changes in inflammation and fat mass through sACE2 modulation.

Six months of calorie restriction (CR) improves T cell mediated function in overweight men and women.

Calorie restriction may be a viable strategy to enhance immune function in overweight individuals.

Serious adverse events were lower in the semaglutide group (13.3%) compared to the placebo group (26.7%) (P < .001).

Semaglutide may offer a safer treatment option for this patient population.

As muscle mass decreases, the risk of conditions like type 2 diabetes rises.

Addressing muscle mass in obesity management could improve health outcomes.

Obesity-related hypertension is a significant contributor to cardiovascular morbidity and mortality.

Healthcare providers should prioritize addressing obesity to mitigate hypertension and related cardiovascular risks.

Übergewicht erhöht die Häufigkeit von Beckenbodenfunktionsstörungen, wobei ein höherer BMI mit einer höheren Prävalenz von Harn- und Stuhlinkontinenz sowie Genitaldeszensus korreliert.

Praktiker sollten Übergewicht als Risikofaktor für Beckenbodenfunktionsstörungen bei Frauen berücksichtigen.

Bei Schwangeren kann Übergewicht das Risiko für postpartale Beckenbodenstörungen deutlich erhöhen.

Praktiker sollten prä- und postpartale Maßnahmen zur Beckenbodengesundheit bei übergewichtigen Schwangeren priorisieren.

Up to 40% of weight loss following treatment with GLP-1RA is accounted for by lean mass.

Clinicians should be aware of potential lean mass loss when prescribing GLP-1RA therapies.

GLP-1 RA use was associated with significantly lower rates of re-tear (RR = 0.699, p < 0.001).

Practitioners may consider GLP-1 RAs as beneficial for reducing re-tear rates in rotator cuff repair patients.

Plant-based protein has differences compared to animal protein that limit its anabolic capacity.

Practitioners should consider the source of protein when advising on muscle maintenance for elderly or vegetarian individuals.

Acute and chronic post-exercise ketosis may stimulate recovery from training.

Practitioners might use ketosis strategies to aid recovery in athletes.

Total thigh muscle volume decreased by 1.7% after 2 days and 5.5% after 7 days of disuse (P<0.001).

Practitioners should be aware that even short periods of disuse can lead to significant muscle loss.

Myofibrillar protein synthesis rates were 36% lower in the immobilized leg compared to the control leg over one week (P<0.001).

Reduced protein synthesis during disuse highlights the importance of maintaining activity to support muscle health.